Surface Carbon Clad Zirconia as Chiral Stationary Phases

描述（由申请人提供）：我们建议研究和开发方法 为了可重复地和经济地合成和使用一类新的手性化合物， 基于碳的正相条件下的固定相（CSP） 表面。这项工作的主要目标将是开发一个商业化的 一种可行的可重复的3微米多孔碳的合成方法 用两个Pirkle型配体，即-（S， S）Whelk-D 1和about-Burke 1。我们将采取的关键新方法是 使用非极性表面作为用于连接手性选择剂的基底。 这种制备手性固定相的方法还没有被广泛应用。 我以前探索过，并认为它提供了显着的优势， 目前的材料。一旦这些阶段开发完成， 为了证明分离几类手性化合物的可行性， 包括F3-阻滞剂的药物。他们会比较分离 与当前技术水平（Pirkie型）CSP偶联到二氧化硅的性能。 我们还将测试进行基本手性分离的可行性 不存在特殊的洗脱液添加剂， 目前需要。该项目将与下列机构密切合作进行： 明尼苏达大学的汤姆·霍耶教授和 卡伯特公司。 拟议商业应用：不可用

DESCRIPTION (provided by applicant): We propose to research and develop means to reproducibly and economically synthesize and use a new class of chiral stationary phases (CSPs) under normal phase conditions based on carbon surfaces. The main goal of this work will be the development a commercially viable reproducible method of synthesizing 3 micron' porous carbon clad-zirconia microsphere derivatized With two Pirkle-typme ligands,namely -(S, S) Whelk-D 1 and about-Burke 1. The key novel approach that we will take is the use of a nonpolar surface, as, the substrate for attaching chiral selectors. This approach to the production of a chiral stationar phase has not been previousl explored and be1ieve that it offers significant advantages over current material's. Once these phases have been developed they will be used to demonstrate'the feasibility of separating several classes of chiral pharmaceuticals including f3-blockers. They will compare separation performance with current state of the art (Pirkie-type) CSPs coupled to silica. We will also test the feasibility of doing chiral separations of basic chiral pharmaceuticals without the presence of special eluent additives, which are currently required. This project will be conducted in close collaboration with Professor Tom Hoye at the University of Minnesota, and Dr. Angelos Kyrlidis at cabot Corporation. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE