FLOW (CYTOMETRY)-BASED UNSCHEDULED DNA SYNTHESIS ASSAY
FLOW (CYTOMETRY)-BASED UNSCHEDULED DNA SYNTHESIS ASSAY
批准号:
6292965
负责人:
EDWARD J YURKOW
金额:
$10.0万
依托单位国家:
美国
项目类别:
财政年份:
2001
资助国家:
美国
项目状态:
已结题
起止时间:
2001-09-01 至 2002-03-31
中文摘要
描述:提出了一种改进的遗传毒性测定方法。
英文摘要
DESCRIPTION: The development of an improved assay for genotoxicity is proposed.
The assay will be based on the Unschedule DNA Synthesis assay that measures
nucleotide incorporation due to repair of DNA damage. The proposal seeks to
modify the assay to use non-radioactive tracers and flow cytometry. The
successful completion of the proposed work will enable the applicant
organization to provide an important new service to the chemical, cosmetic,
consumer products and safety-testing industries.
PROPOSED COMMERCIAL APPLICATION:
MB Research will conduct this assay of genotoxicity (in-house) for members of the pharmaceutical, biotech, cosmetic, agrochemical, chemical and consumer products industries. Our clients are increasingly requesting rapid, reliable and inexpensive assays of genotoxicity (see letters from Brayer, Avon, and Perdue Pharma) that would be used to screen large numbers of chemicals. The results of such an assay would be used to determine which chemicals should be excluded from the product development process and which agents should move on to further tests of genotoxicity.
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会议论文
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批准号:10175413
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项目类别:
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资助金额:$22.56万
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财政年份:2021
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负责人:EDWARD J YURKOW
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依托单位:
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批准号:6210363
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项目类别:
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资助金额:$10.0万
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财政年份:2000
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负责人:EDWARD J YURKOW
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依托单位:
海外基金