CORE--GNOTOBIOLOGY AND DIAGNOSTIC LABORATORY SERVICES

核心单位-生物学和诊断实验室服务 核心单元将以高度互动和 合作的基础。将提供四种基本服务。 1. Gnotobiology技术服务-包括无菌 隔离器的制造、修改、设计和设置， 啮齿动物将为设计提供技术专门知识和支持， 特殊HEPA过滤器的建造、操作和维护 用于饲养免疫功能低下的狗和灵长类动物的围栏。 将提供净化和后勤支助，以及 高压灭菌和消毒设备，食品，水和其他 用品.啮齿动物剖腹产及其他特殊操作 将提供。 2.无菌啮齿动物和无菌啮齿动物的饲养-常规饲养 （喂食、浇水、换笼等）将为所有啮齿动物提供 在无菌隔离器中。将提供类似的饲养和护理， 研究中的SCID啮齿动物被圈养在特殊的HEPA过滤外壳中， 生物系动物实验室核心将与 大学实验室动物资源关于动物护理相关活动 按要求 3.诊断实验室服务-现有的研究实验室设施 在实验动物医学和兽医病理学将提供 诊断支持。该支持将表征并确保微生物 研究中使用的动物状态，并将调查和确保 无菌隔离器的适当环境条件，HEPA 过滤的容纳外壳，以及其他动物被 安置好了 4.行政支助-核心部门将为以下方面提供行政支助： 项目负责人，并将协调所有动物护理和使用事宜， 合适的大学办公室。

Core Unit- Gnotobiology and Diagnostic Laboratory Services The core unit will serve all projects in a highly interactive and collaborative basis. Four basic types of services will be provided. 1. Technical Services for Gnotobiology- This will include germ free isolator fabrication, modification and design and set-up as required for rodents. Technical expertise and support will be provided for the design, construction, manipulation and maintenance of special HEPA filtered enclosures for housing immunocompromised dogs and primates. Decontamination and logistical support will be provided, as well as autoclaving and decontaminating equipment, food, water, and other supplies. Cesarean derivation of rodents and other special manipulation will be provided. 2. Housing for Germ free and Gnotobiotic Rodents- Routine husbandry (feeding, watering, cage changing, etc.) will be provided for all rodents in germ free isolators. Similar husbandry and care will be provided for SCID rodents on study while housed in special HEPA filtered enclosures in the Department of Biology animal facility. The core will coordinate with University Laboratory Animal Resources on animal care related activities as required. 3. Diagnostic Laboratory Services- Existing research laboratory facilities in Laboratory Animal Medicine and in Veterinary Pathobiology will provide diagnostic support. This support will characterize and assure microbial status of animals used in the studies and will survey and assure appropriate environmental conditions for germ free isolators, HEPA filtered containment enclosures, and other areas in which animals are housed. 4. Administrative Support- The core will provide administrative support to project leaders and will coordinate all animal care and use matters with appropriate university offices.