AIDS RELATED NONHODGKIN'S LYMPHOMA/KAPOSI'S SARCOMA AND OTHER MALIGNANCIES

迄今为止，已从15家临床中心入组了1135例患者。 数据来自978例患者，代表584人-年的随访。 其中，756人（77%）是男性，222人（23%）是女性; 419人（43%）是白色，526人（54%）是非洲裔美国人，23人（2%）是西班牙裔。平均年龄为40岁。 HIV传播因素包括497例（51%）同性性行为和278例（28%）注射毒品。 中位CD 4计数（最近）为168/mm 3（平均200/mm 3），中位HIV-1 RNA为44，473 c/mL（平均184，351 c/mL）。 72例（7%）患者在入组前被诊断为milagelatin，包括7例（10%）NHL和27例（37%）KS。 迄今为止，自入组以来，11例患者（1%）被诊断患有12种恶性肿瘤：KS（n=3）、NHL（1）、原发性CNS淋巴瘤（1）、皮肤癌（3）、肺癌（3）和舌鳞状细胞癌（1）。 此外，4名妇女被诊断为宫颈发育不良。

1135 patients have been enrolled to date from 15 clinical centers. Data are available from 978 patients, representing 584 person-years of follow-up. Of those, 756 (77%) are male and 222 (23%) are female; 419 (43%) are white, 526 (54%) are African-American, and 23 (2%) are Hispanic. Mean age is 40 years. HIV transmission factors included homosexual sex in 497 (51%) and injection drug use in 278 (28%). Median CD4 count (most recent) is 168/mm3 (mean 200/mm3) and median HIV-1 RNA is 44,473 c/mL (mean 184,351 c/mL). 72 (7%) had been diagnosed with a milagnancy prior to enrollment, including 7 (10%) with NHL and 27 (37%) with KS. To date 11 patients (1%) have been diagnosed with 12 malignancies since enrollment: KS (n=3), NHL (1), primary CNS lymphoma (1), skin cancer (3), lung cancer (3), and squamous cell carcinoma of the tongue (1). In addition, 4 women were diagnosed with cervical dysplasia.