AIDS RELATED NONHODGKIN'S LYMPHOMA/KAPOSI'S SARCOMA AND OTHER MALIGNANCIES

迄今为止，已有来自15个临床中心的1135名患者入组。数据来自978名患者，代表584人年的随访。其中男性756人（77%），女性222人（23%）；419人（43%）是白人，526人（54%）是非裔美国人，23人（2%）是西班牙裔。平均年龄为40岁。艾滋病毒的传播因素包括同性恋性行为497例（51%）和注射毒品278例（28%）。中位CD4计数（最近）为168/mm3（平均200/mm3），中位HIV-1 RNA为44,473 c/mL（平均184,351 c/mL）。72例（7%）在入组前被诊断为妊娠，其中7例（10%）为NHL， 27例（37%）为KS。自入组以来，迄今已有11例（1%）患者被诊断患有12种恶性肿瘤：KS （n=3）、NHL(1)、原发性中枢神经系统淋巴瘤(1)、皮肤癌(3)、肺癌(3)和舌鳞癌(1)。此外，4名妇女被诊断为宫颈发育不良。

1135 patients have been enrolled to date from 15 clinical centers. Data are available from 978 patients, representing 584 person-years of follow-up. Of those, 756 (77%) are male and 222 (23%) are female; 419 (43%) are white, 526 (54%) are African-American, and 23 (2%) are Hispanic. Mean age is 40 years. HIV transmission factors included homosexual sex in 497 (51%) and injection drug use in 278 (28%). Median CD4 count (most recent) is 168/mm3 (mean 200/mm3) and median HIV-1 RNA is 44,473 c/mL (mean 184,351 c/mL). 72 (7%) had been diagnosed with a milagnancy prior to enrollment, including 7 (10%) with NHL and 27 (37%) with KS. To date 11 patients (1%) have been diagnosed with 12 malignancies since enrollment: KS (n=3), NHL (1), primary CNS lymphoma (1), skin cancer (3), lung cancer (3), and squamous cell carcinoma of the tongue (1). In addition, 4 women were diagnosed with cervical dysplasia.