VENTILATOR SUPPORT & EARLY CORTICOSTEROID THERAPY

呼吸机支架

• 批准号: 6265835
• 负责人: RICHARD A. EHRENKRANZ
• 金额: $ 2.58万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6265835
• 关键词: clinical research; combination therapy; corticosteroids; drug administration rate /duration; hormone therapy; human subject; human therapy evaluation; hypercapnia; infant mortality; low birth weight infant human; respirators; respiratory disease /disorder therapy; respiratory disorder chemotherapy; respiratory distress syndrome of newborn

A ventilatory strategy of minimal ventilator support (permissive hypercapnia) before 12 hours and continued for 10 days or until extubation and/or a stress dose of corticosteroid (CS) started before 24 hours and tapered over 10 days will be evaluated to determine whether the incidence of death before discharge or chronic lung disease in extremely low birthweight infants can be reduced. (This is an NICHD Neontal Research Network protocol.)

将评价12小时前最低限度呼吸机支持（允许性高碳酸血症）并持续10天或直至拔管和/或24小时前开始皮质类固醇（CS）负荷剂量并在10天内逐渐减量的治疗策略，以确定极低出生体重儿出院前死亡或慢性肺部疾病的发生率是否可以降低。 (This是NICHD神经网络研究网络协议。）