课题基金 / 基金详情

BIOCHEMICAL MODULATION OF 5-FLUOROURACIL AND LEUCOVORIN IN COLORECTAL CANCER

BIOCHEMICAL MODULATION OF 5-FLUOROURACIL AND LEUCOVORIN IN COLORECTAL CANCER
5-氟尿嘧啶和亚叶酸在结直肠癌中的生化调节
批准号：
6122723
负责人：
FREDERICK RICHARDS
金额：
$3.88万
依托单位：
WAKE FOREST UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6122723
关键词：
N phosphonoacetyl L aspartate chemosensitizing agent clinical research clinical trial phase I colorectal neoplasms combination chemotherapy drug resistance drug screening /evaluation fluorouracil human subject human therapy evaluation leucovorin neoplasm /cancer chemotherapy

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英文摘要
The development or resistance to anti-cancer drugs is the principal cause of chemotherapy failure in cancer patients. The goal of this study is to increase the response to the anti-cancer agent 5-fluorouracil by overcoming tumor cell resistance with a second anti-cancer agent PALA. This study uses a 3X3 factorial design to assess the joint effects of PALA, leucovorin and fluorouracil on various biochemical endpoints in patients with resectable colorectal cancer. The results will provide a basis for improving therapy.
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BIOCHEMICAL MODULATION OF 5-FLUOROURACIL AND LEUCOVORIN IN COLORECTAL CANCER
  • 批准号：
    6253739
  • 项目类别：
  • 资助金额：
    $3.61万
  • 财政年份：
    1997
  • 负责人：
    FREDERICK RICHARDS
  • 依托单位：
    WAKE FOREST UNIVERSITY
BIOCHEMICAL MODULATION OF 5-FLUOROURACIL AND LEUCOVORIN IN COLORECTAL CANCER
  • 批准号：
    6282758
  • 项目类别：
  • 资助金额：
    $3.63万
  • 财政年份：
    1997
  • 负责人：
    FREDERICK RICHARDS
  • 依托单位：
    WAKE FOREST UNIVERSITY
BIOCHEMICAL MODULATION OF 5-FLUOROURACIL AND LEUCOVORIN IN COLORECTAL CANCER
  • 批准号：
    6309897
  • 项目类别：
  • 资助金额：
    $3.88万
  • 财政年份：
    --
  • 负责人：
    FREDERICK RICHARDS
  • 依托单位：
    WAKE FOREST UNIVERSITY