CORTISOL METABOLISM IN CHILDREN W/ CHRONIC RENAL FAILURE

慢性肾功能衰竭儿童的皮质醇代谢

• 批准号: 6265812
• 负责人: EDUARDO M PERELSTEIN
• 金额: $ 8.26万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6265812
• 关键词: blood pressure; child (0-11); chronic renal failure; clinical research; cortisol; human subject; metal metabolism; potassium; steroid metabolism; urinalysis

We propose to study cortisol metabolism in children with renal failure. We suggest that these patients are not capable of converting cortisol to cortisone and weil will measure the urinary excretion of cortisol and its metabolites in order to prove this. We will observe the effects of this alteration on blood pressure and K+ metabolism.

我们建议研究肾功能衰竭儿童的皮质醇代谢。 我们认为这些患者不能将皮质醇转化为可的松，为了证明这一点，威尔将测量皮质醇及其代谢产物的尿排泄量。 我们将观察这种改变对血压和K+代谢的影响。