课题基金 / 基金详情

HEART AND ESTROGEN/PROGESTIN REPLACEMENT STUDIES

HEART AND ESTROGEN/PROGESTIN REPLACEMENT STUDIES
心脏和雌激素/孕激素替代研究
批准号：
6122718
负责人：
DAVID McLeod HERRINGTON
金额：
$3.88万
依托单位：
WAKE FOREST UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6122718
关键词：
cancer prevention cardiovascular disorder prevention chemoprevention clinical research coronary disorder estrogens female hormone therapy human subject human therapy evaluation postmenopause progestins uterus neoplasms

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Coronary heart disease (CHD) is the leading cause of death in women. Observational studies suggest that postmenopausal estrogen replacement therapy (ERT) reduces the risk of a new CHD event by 50% in healthy women, and by 80% in women with prior CHD. Whether the addition of progestin (PERT) to prevent estrogen-induced endometrial cancer alters the risk of CHD is unknown. A total of 3,252 postmenopausal women with coronary disease are being randomized to one of three blinded regimens: ERT, PERT or placebo.
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