NEUROPSYCHOLOGICAL TESTING FOR CHILDREN AND ADULTS WITH

医学疾病咨询中心（MICC）应支持国家癌症研究所临床科学部艾滋病毒和艾滋病咨询分支（HAMB）的研究工作，通过使用心理测量测试和神经心理学评估的纵向研究，评估慢性医学疾病成人和儿童的心理异常状况以及行为、认知和运动能力的发育进展，如艾滋病和癌症。他们将研究适当的治疗对这些心理功能的影响。 MICC应提供全面的，最先进的神经心理学和行为评价的儿童和成人HAMB患者与艾滋病毒感染和/或癌症可能其他NIH患者。综合评价应包括对以下功能领域的评估：一般智力、语言、视觉空间、感知和建构能力、注意力和集中力、概念形成和判断、运动强度和速度、执行功能、适应行为、学习和记忆。 MICC应根据现有数据开发对CNS的疾病特异性影响以及治疗或疾病进展变化敏感的神经认知功能综合监测组合。他们应通过适当的评估提供神经行为测量，以进一步研究这些患者的脑病、痴呆或神经心理异常的发病机制。 这可能包括探索神经行为测量与免疫学、血液学、病毒学、神经学（脑成像研究）、遗传学、生物化学和生理学变量之间的关系。

The Medical Illness Counseling Center (MICC) shall support the research effort of the HIV and AIDS Malignancy Branch (HAMB) in the Division of Clinical Sciences, National Cancer Institute by assessing, through longitudinal studies using psychometric testing and neuropsychological evaluation, the status of psychological abnormalities and developmental progress in behavior, cognition, and motor abilities of adults and children with chronic medical illness, such as HIV disease and cancer. They will investigate the effect of appropriate treatments on these psychological functions. MICC shall provide comprehensive, state of the art neuropsychological and behavioral evaluations of pediatric and adult HAMB patients with HIV infection and possibly other NIH patients with HIV and/or cancer. The comprehensive evaluations shall include an assessment of the following domains of function: General Intelligence, language, visual spatial, perceptual, and constructive abilities, attention and concentration, concept formation and judgment, motor strength and speed, executive function, adaptive behavior, learning and memory. MICC shall develop, based on existing data, comprehensive and monitoring batteries of neurocognitive functions that are sensitive to disease specific effects on the CNS and to changes with therapy or disease progression. They shall provide neurobehavioral measures through appropriate assessments to further investigate the pathogenesis of the encephalopathy, dementia, or the neuropsychological abnormalities in these patients. This may include exploring relations between neurobehavioral measures and immunological, hematological, virological, neurological (brain imaging studies), genetic, biochemical and physiological variables.