PEDIATRIC STUDY CENTERS (PSCS) FOR A MRI STUDY OF NORMAL

这是一项由NINDS、NIMH和NICHD赞助的婴儿和儿童正常结构和代谢脑发育的多中心研究。将使用磁共振成像（MRI）和磁共振波谱（MRS）来表征0至18岁之间大脑发育与行为和认知的关系，并辅以0至4岁的弥散张量成像（DTI）。该项目计划为期六年，包括纵向设计、重复行为测试和重新扫描受试者。该项目将产生一个具有代表性、可靠和充分的数据库，用于描述正常大脑发育，构建生长曲线以评估个体大脑，为患者研究提供潜在的控制数据，并创建发育敏感的图像分析工具。将实施一项数据共享计划，以便向医学界和研究界提供这一资源。

This is a multi-center study of normal structural and metabolic brain development in infants and children, being sponsored by NINDS, NIMH and NICHD. Magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) will be used to characterize brain development in relationship to behavior and cognition from ages 0 through 18 years, supplemented by diffusion tensor imaging (DTI) for ages 0 through 4 years. The project is planned for six years and involves a longitudinal design, repeated behavioral testing, and rescanning of subjects. This project will result in a representative, reliable and adequate database with which to characterize normal brain development, construct growth curves with which to evaluate individual brains, provide potential control data for studies of patients, and create developmentally-sensitive image analysis tools. A data sharing plan will be implemented to make this resource available to the medical and research community.