CORE--PEPTIDE SYNTHESIS, PURIFICATION, FOLDING AND STRUCTURAL ANALYSIS FACILITY

核心——肽合成、纯化、折叠和结构分析设备

• 批准号: 6340689
• 负责人: ALAN J WARING
• 金额: $ 15.97万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2001-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6340689
• 关键词: antibiotics; biomedical facility; chemical registry /resource; drug design /synthesis /production; peptide chemical synthesis; peptides; protein folding; protein purification; protein structure function

Core is responsible for preparing the various peptides. Protegrins will generally be synthesized by Dr. Waring at the UCLA site. LL-37 and related alpha-helical peptides will be synthesized by Dr. Pohl at Emory, as will any protegrins that would be benefit from t-boc synthesis. The availability of high-quality peptides is absolutely essential for the proposed studies. Dr. Waring and Pohl are highly accomplished investigators with access to state-of-the-art tools for peptide synthesis, purification and characterization.

核心负责制备各种肽。 Protegrins通常由Waring博士在UCLA工厂合成。 LL-37和相关的α-螺旋肽将由埃默里大学的Pohl博士合成，任何从t-boc合成中受益的protegrins也将如此。 高质量肽的可用性对于所提出的研究是绝对必要的。 Waring博士和Pohl博士都是非常有成就的研究人员，能够使用最先进的工具进行肽合成，纯化和表征。