Droperidol and olanzapine as adjuncts to midazolam for the acutely agitated patient: a randomised clinical trial

氟哌利多和奥氮平作为咪达唑仑的辅助治疗急性躁动患者：一项随机临床试验

• 批准号: nhmrc : 628501
• 负责人: A/Pr Jonathan Knott
• 金额: $ 12.53万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/droperidol-olanzapine-adjuncts-clinical-trial/95774
• 关键词: Droperidol; olanzapine; adjuncts; midazolam; acutely

Management of the acutely agitated patient, whether due to severe psychiatric illness or drug intoxication, results in a disproportionate use of Emergency Department resources. Drug sedation is frequently employed when an individual is at risk of harming themselves or others. This study will determine if antipsychotic drugs (droperidol and olanzapine), when added to midazolam (a commonly used sedative), is safer and more efficacious than sedation with midazolam alone.

对急性躁动患者的管理，无论是由于严重的精神疾病还是药物中毒，都会导致急诊科资源的过度使用。当一个人有伤害自己或他人的风险时，经常使用药物镇静。这项研究将确定抗精神病药物（氟哌利多和奥氮平）添加到咪达唑仑（一种常用镇静剂）中是否比单独使用咪达唑仑镇静更安全、更有效。