Droperidol and olanzapine as adjuncts to midazolam for the acutely agitated patient: a randomised clinical trial

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Management of the acutely agitated patient, whether due to severe psychiatric illness or drug intoxication, results in a disproportionate use of Emergency Department resources. Drug sedation is frequently employed when an individual is at risk of harming themselves or others. This study will determine if antipsychotic drugs (droperidol and olanzapine), when added to midazolam (a commonly used sedative), is safer and more efficacious than sedation with midazolam alone.