Drug glucuronidation - An integrated approach

药物葡萄糖醛酸化 - 一种综合方法

• 批准号: nhmrc : 595920
• 负责人: Dr Thomas Polasek
• 金额: $ 35.78万
• 依托单位: Flinders University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/drug-glucuronidation-an-integrated-approach/77200
• 关键词: Drug; glucuronidation; integrated; approach

Drugs are broken down in the body by the process of metabolism. Metabolism is important as both a detoxification and elimination mechanism, and determines dose rate for chronically administered drugs. Many drugs are metabolised by a reaction called glucuronidation. We will characterise the various components of the glucuronidation reaction in an integrated manner in order to understand and predict factors that influence an individual's capacity to metabolise drugs and other chemicals.

药物在体内通过新陈代谢过程被分解。代谢作为解毒和消除机制都很重要，并决定长期给药药物的剂量率。许多药物通过一种称为葡萄糖醛酸化的反应代谢。我们将以综合的方式分析葡萄糖醛酸化反应的各个组成部分，以了解和预测影响个体代谢药物和其他化学物质的能力的因素。