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MECHANISM OF INCREASED PLASMA APO A1 LEVELS BY ESTROGENS

MECHANISM OF INCREASED PLASMA APO A1 LEVELS BY ESTROGENS
雌激素提高血浆 APO A1 水平的机制
批准号：
6304531
负责人：
ERNST JOHN SCHAEFER
金额：
$4.27万
依托单位：
TUFTS MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
项目状态：
已结题
起止时间：
1999-12-01 至 2001-02-28
来源：
https://reporter.nih.gov/project-details/6304531
关键词：
apolipoproteins blood lipoprotein metabolism clinical research coronary disorder disease /disorder proneness /risk estrogens female hormone regulation /control mechanism hormone therapy human subject human therapy evaluation medroxyprogesterone postmenopause

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英文摘要
Postmenopausal women are at higher risk of coronary heart disease (CHD) than premenopausal women, even after controlling for age-effects. However, estrogen replacement therapy significantly lowers the risk of CHD in postmenopausal women. With this study, we propose to determine the kinetics of apolipoprotein A-I, the major protein component of high density lipoproteins, in postmenopausal women undergoing a placebo-controlled, randomized treatment with each of the following regimens:a)placebo,b)0.625mg/d conjugated estrogens, and c)0.625mg/d conjugated estrogens.
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