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L DOPS IN NEUROGENIC ORTHOSTATIC HYPOTENSION

L DOPS IN NEUROGENIC ORTHOSTATIC HYPOTENSION
L DOPS 治疗神经源性直立性低血压
批准号：
6305207
负责人：
HORACIO KAUFMANN
金额：
$4.76万
依托单位：
MOUNT SINAI SCHOOL OF MEDICINE OF CUNY
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
项目状态：
已结题
起止时间：
1999-12-01 至 2001-02-28
来源：
https://reporter.nih.gov/project-details/6305207
关键词：
autonomic disorder blood pressure cardiovascular disorder chemotherapy clinical research clinical trials dihydroxyphenylalanine drug adverse effect drug screening /evaluation human subject human therapy evaluation norepinephrine pharmacokinetics postural hypotension

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中文摘要
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英文摘要
This protocol will (a) determine whether L-DOPS, a synthetic precursor of norepinehprine, increases blood pressure and improves quality of life in patients with autonomic failure, and (2) determine the mechanism- and site-of-action for the pressor effects of L-DOPS.
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Phase 2 Norepinephrine Transporter Blockade, Autonomic Failure IND117394 12/28/12
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