METFORMIN EFFECTS ON LEPTIN LEVELS AND BODY COMPOSITION IN OBESE CHILDREN

二甲双胍对肥胖儿童瘦素水平和身体成分的影响

• 批准号: 6307435
• 负责人: ALAN D ROGOL
• 金额: $ 2.81万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2001-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6307435
• 关键词: body composition; child (0-11); clinical research; endocrine disorder chemotherapy; human data; human subject; human therapy evaluation; hyperinsulinism; leptin; metformin; obesity

Leptin is produced solely in adipose tissue and appears to serve as a regulator of several metabolic, hypothalamic and anterior pituitary functions. In humans, leptin levels rise in concordance with adiposity as measured by body mass index and levels correlate most closely with subcutaneous fat stores. We will compare baseline leptin levels and body composition in obese children to those available in nonobese peers and study the effects of metformin on these parameters in obese children with hyperinsulinism.

瘦素仅在脂肪组织中产生，并且似乎充当若干代谢、下丘脑和垂体前叶功能的调节剂。 在人类中，瘦素水平的上升与肥胖一致，如通过体重指数测量的，并且瘦素水平与皮下脂肪储存最密切相关。 我们将比较肥胖儿童与非肥胖儿童的基线瘦素水平和身体成分，并研究二甲双胍对高胰岛素血症肥胖儿童这些参数的影响。