INFLUENZA PANDEMIC PREPAREDNESS IN ASIA

亚洲流感大流行的防范

• 批准号: 6292644
• 负责人: ROBERT G. WEBSTER
• 金额: --
• 依托单位: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-01-08 至 2006-01-07
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6292644
• 关键词: Asia; Aves; biomedical resource; influenza; influenzavirus A; microorganism population study; microorganism resource /registry

Influenza viruses are recognized for their ability to cause serious infection and disease, in all age-groups of people. These annual influenza epidemics vary in severity, and are attributable to the way in which these viruses undergo rapid genetic evolution. Up until late 1997, this century~s historical record suggested that only H1, H2 and H3 subtypes could affect humans. However this assumption came unraveled in the face of the H5N1 outbreak in Hong Kong in which 18 people became infected with an H5N1 avian (chicken) influenza virus. Six of these cases were fatal. While it is recognized that avian and swine (pig) viruses can infect man without reassortment of the viral genes, the nature of the human cases in Hong Kong aroused great concern that we were possibly facing the beginning of a pandemic. The transmission of H5N1 influenza viruses from domestic poultry to humans emphasizes the need to have information available on all influenza subtypes circulating in the animal reservoirs of the world. It is well established that the aquatic birds of the world perpetuate each of the known subtypes of influenza viruses. However, it is not known which subtypes and variants are dominant. It is essential for the control of pandemic influenza that we implement systematic and continuous surveillance for influenza viruses in birds and animals of the world, particularly in Asia, and production and storage of viruses, reagents and technologies to facilitate rapid characterization and exchange of information. It is also essential to understand the fundamental differences between the Eurasian and American lineages of influenza viruses, the molecular changes that occur when influenza viruses transmit to other hosts and the dominance of particular subtypes in their natural reservoirs. If we can gain knowledge on these issues, we might be better prepared to respond rapidly to an emerging influenza pandemic.

流感病毒因其在所有年龄组人群中引起严重感染和疾病的能力而得到承认。这些年度流感大流行的严重程度各不相同，这可归因于这些病毒经历快速遗传进化的方式。直到1997年底，本世纪的历史记录表明，只有H1、H2和H3亚型会影响人类。然而，面对香港爆发的H5N1禽流感疫情，这种假设被推翻了，其中18人感染了H5N1禽流感（鸡）病毒。其中6例死亡。虽然我们知道禽流感和猪（猪）病毒可以感染人类而无需重组病毒基因，但香港人类病例的性质引起了人们的极大关注，我们可能正面临一场大流行的开始。H5N1流感病毒从家禽向人类的传播强调了有必要提供有关世界动物宿主中流行的所有流感亚型的信息。众所周知，世界上的水禽会传播每一种已知的流感病毒亚型。然而，尚不清楚哪些亚型和变体占主导地位。控制大流行性流感至关重要的是，我们对世界上特别是亚洲的禽鸟和动物的流感病毒实施系统和持续的监测，并生产和储存病毒、试剂和技术，以促进快速鉴定和信息交流。了解欧亚和美洲流感病毒谱系之间的根本差异、流感病毒传播到其他宿主时发生的分子变化以及特定亚型在其自然宿主中的主导地位也至关重要。如果我们能够获得关于这些问题的知识，我们可能会更好地准备迅速应对新出现的流感大流行。