SECOND GENERATION TOOLS FOR FUNCTIONAL GENOMICS

第二代功能基因组学工具

• 批准号: 6298635
• 负责人: Stephen G Chamberlin
• 金额: $ 36.82万
• 依托单位: ERAGEN BIOSCIENCES, INC.
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-01 至 2003-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6298635
• 关键词: biochemical evolution; computer program /software; computer system design /evaluation; conformation; functional /structural genomics; gene expression; molecular biology information system; molecular genetics; nucleic acid sequence; protein sequence; technology /technique development

APPLICANT?S DESCRIPTION: EraGen will develop a new functional genomics software suite that helps scientists use genomic sequence data to solve biological and biomedical problems in this Phase II period. The product will take the scientist beyond classical approaches to sequence annotation, which use BLAST searches to identify homologs, and assume that two proteins related by common ancestry must have analogous functions. The Phase I period demonstrated that this approach to database annotation is often misleading, and frequently misses meaningful interpretations in metazoan proteins. The Phase II period will refine and fully develop the software initiated in Phase I. This software will serve to identify where function might have changed during divergence of a sequence family, and also where recruitment of function has occurred using rates of change from the DNA sequence. In addition, the tools to exploit probabilistic ancestral sequences for both protein/protein and DNA/protein alignments will be fully developed. These tools will detect distant homologs, identify errors across sequence databases, and augment current approaches to gene finding. PROPOSED COMMERCIAL APPLICATIONS: Not Available

申请人?描述：EraGen将开发一款新的功能基因组软件