CORE--GENE TARGETED MOUSE FACILITY

这部PPG的一个中心主题是转基因小鼠。这个核心是位于洛克菲勒大学的基因靶向老鼠设施。该设施将提供将在每个子项目中使用的基因=靶向小鼠。蒙巴茨博士在洛克菲勒大学的实验室里已经研制出了这些小鼠中的大多数。新的菌株将被开发并存放在这个岩芯中。因为在其他机构复制这些品系的小鼠成本很高，而且质量控制必须严格，我们选择使用一个单一的设施，通过这个设施将小鼠分发给每个小组。集中培育基因靶向的小鼠不会构成障碍，因为各个实验室在地理上很接近。

A central theme in this PPG is the genetically engineered mouse. This Core is the Gene-Targeted Mouse Facility, located at The Rockefeller University. The facility will provide the gene=targeted mice that will be used in each of the subprojects. Most of these mice have already been developed by Dr. Mombaerts in his laboratory at The Rockefeller University. New strains will be developed and deposited in this core. Because duplicating these lines of mice at other institutions is costly and because quality control must be stringent, we have elected to utilize a single facility through which mice will be distribute to each of the groups. Centralized breeding of the gene-targeted mice will not pose a hurdle because of the geographical proximity of the various laboratories.