A7: COMPUTATIONAL STUDY ON HLTH RELATED PHENOMENA: MOLEC MODEL OF BIOL PROCESSES

生化与化学分子模拟中心 进程。分子建模已经成为一个必不可少的工具 生物医学研究活动。建议的研究是有针对性的 向现象的计算研究迈进，这将导致更好的 对生物和生化的分子基础的认识 流程。化学系的几位教职员工 和生物学将参与由以下项目支持的研究活动 分子建模和计算化学预测。其中 研究项目是对DNA的光切割进行研究。 拉曼光谱在多环芳烃研究中的应用 监测乳房组织损伤，调查急性毒性 砷和阿特拉津对大鼠和鱼类影响的研究 对晶状体和角膜结构完整性的影响，以及 不同环境效应对大气环境影响的计算研究 DNA自发突变的可能性。最后一个项目是 纯粹是推测性的；所有其他研究计划将结合 实验研究和计算密集型计算 将需要复杂的分子建模和计算 基础设施。该中心的建立将促进 JSU的合作研究努力，并将创建一个 杰克逊地区教职员工的计算生物医学研究 大学和医疗中心。

A Center for Molecular Modeling of Biochemical and Chemical Processes. Molecular modeling has become an essential tool in biomedical research activities. The proposed research is directed towards computational studies of phenomena which will lead to a better understanding of molecular bases of biological and biochemical processes. Several faculty members of the Departments of Chemistry and Biology will be involved in the research activities supported by the molecular modeling and computational chemistry predictions. Among the research projects are studies of photocleavage of DNA by Polycyclic Aromatic Hydrocarbons, application of Raman spectroscopy in monitoring breast tissue damage, investigations of acute toxicity of arsenic and atrazine in rats and fish, study of the effect of various agents on the structural integrity of the lens and cornea, and computational studies of different environmental effects on the probability of spontaneous mutations in DNA. The last project is purely co mputational; all other research initiatives will combine experimental studies and computationally intensive calculations which will require sophisticated molecular modeling and computational infrastructure. The establishment of the Center will facilitate collaborative research efforts at JSU and will create a hub for computational biomedical studies for faculty members from Jackson area colleges and medical centers.