A new therapeutic target for proteasome inhibitor resistant multiple myeloma

多发性骨髓瘤（MM）是一种无法治愈的血癌，迫切需要新的治疗策略。虽然MM患者从药物硼替佐米添加到治疗方案中获益匪浅，但对硼替佐米的耐药性不可避免地发生。该提案将研究如何通过使用我们最近开发的新药物靶向脂质代谢来重新敏感硼替佐米耐药MM。通过这样做，我们希望发现新的疗法来延长MM患者的生命。

Multiple myeloma (MM) is an incurable blood cancer for which novel therapeutic strategies are urgently required. Although MM patients have greatly benefited from the addition of the drug bortezomib to therapeutic regimens, resistance to bortezomib inevitably occurs. This proposal will examine ways to re-sensitise bortezomib-resistant MM by targeting lipid metabolism using new agents we have recently developed. By doing so, we hope to discover new therapies to extend the lives of MM patients.