Alternative Strategies in the Prevention on HIV/STDS

预防艾滋病毒/性传播疾病的替代策略

• 批准号: 6454693
• 负责人: CLYDE B MCCOY
• 金额: $ 57.59万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-30 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6454693
• 关键词: AIDS education /prevention; HIV infections; behavioral /social science research tag; clinical trials; cognitive behavior therapy; crack cocaine; enzyme linked immunosorbent assay; health behavior; high risk behavior /lifestyle; human immunodeficiency virus; human subject; human therapy evaluation; interview; longitudinal human study; patient oriented research; psychometrics; questionnaires; safe sex /sex abstinence; sex behavior; sexually transmitted diseases; smoking; statistics /biometry; substance abuse related behavior; urinalysis; western blottings

DESCRIPTION (provided by applicant): This three-arm prospective experimental study of interventions to reduce high-risk sexual behaviors among 750 crack users will compare two behavioral interventions with a comparison group that receives usual HIV pretest- posttest counseling. Aims include (1) evaluating the effectiveness of the interventions, (2) examining changes in mediators of the intervention efforts, and (3) determining how well the interventions' effects are maintained over time. The two behavioral interventions are: (a) Project Respect, which has been demonstrated effective in changing sexual risk behaviors and is here applied to crack users; and (b) Project Respect Plus, modified by our investigators to specifically target alternative, less effective strategies for sexual risk-reduction that our formative research has shown to be common among crack smokers. This innovative intervention addresses the crack user lifestyle and the lay belief systems regarding HIV prevention in sexual situations. Outreach staff will recruit participants from six diverse neighborhoods in Miami/Dade County, Florida, and will randomly assign participants to one of the three arms using geographical randomization with a crossover design, which has been designed to reduce contamination within geographical and social groupings of drug users. This study design allows us to estimate the effects of each of the behavioral interventions over and above the impact of methodological effects (i.e. the effects of pre and post-test counseling and repeated measurement of behaviors). Sample size is sufficient to ensure adequate power to detect effects on sexual risk behavior. Follow-up over 18 months will allow us to assess how well the changes attributed to the interventions are sustained. The investigators have a long history of community-based research with similar populations.

描述(申请人提供)：本次三臂前瞻性实验 750名吸毒人员减少高危性行为干预研究 用户将两种行为干预与对照组进行比较， 接受通常的艾滋病毒检测前和检测后咨询。目标包括(1)评估 干预措施的有效性，(2)检查调解人的变化 干预努力，以及(3)确定干预措施的效果 效果会随着时间的推移保持不变。这两种行为干预措施是：(A) 项目尊重，这已被证明在改变性风险方面有效 行为，并在这里适用于破解用户；和(B)Project尊重Plus， 由我们的调查人员进行修改，以专门针对替代方案，减少 我们的形成性研究提出了有效的减少性风险的策略 在吸毒者中很常见。这一创新的干预解决了 吸毒人群的生活方式与艾滋病预防的世俗信念体系 性生活状况。外展人员将从六个不同的人中招募参与者 佛罗里达州迈阿密/戴德县的社区，并将随机分配 使用地理随机化的三个手臂之一的参与者 交叉设计，旨在减少内部污染 吸毒者的地理和社会分组。这项研究设计使我们能够 估计每种行为干预措施的影响 方法学效果的影响(即前后测试的效果 咨询和重复测量行为)。样本量足以 确保有足够的权力来检测对性危险行为的影响。后续行动结束 18个月将使我们能够评估归因于 干预是持续的。调查人员有很长的历史 以社区为基础的类似人群的研究。