CEREBROSPINAL FLUID MARKERS OF AGING AND BRAIN DISEASE
CEREBROSPINAL FLUID MARKERS OF AGING AND BRAIN DISEASE
批准号:
6413958
负责人:
Stanley I. Rapoport
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
关键词:
Alzheimer's disease aging biomarker brain disorder diagnosis cerebrospinal fluid clinical research cytokine receptors diagnosis design /evaluation enzyme linked immunosorbent assay human old age (65+) human subject interleukin 6 major depression mental disorder diagnosis neurofibrillary tangles tau proteins
中文摘要
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英文摘要
Tau protein is was found to be elevated in the cerebrospinal fluid (CSF) of patients with Alzheimer disease (AD), reflecting neurofibrillary tangle formation. CSF tau concentrations, when combined with age in a discriminant function analysis, increased the power to maker a correct diagnosis of AD in subjects less than 70 years old. Interleukin 6 (IL-6) contributes to the interaction between immune mechanisms and brain. CSF concentrations from geriatric patients with major depression showed significantly reduced levels of both IL-6 and the soluble Il-6 receptor (sIL-6R), measured by enzyme-linked immunosorbant assays (ELISA), compared with control CSF.
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会议论文
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海外基金