CEREBROSPINAL FLUID MARKERS OF AGING AND BRAIN DISEASE

衰老和脑部疾病的脑脊液标志物

• 批准号: 6413958
• 负责人: Stanley I. Rapoport
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6413958
• 关键词: Alzheimer's disease; aging; biomarker; brain disorder diagnosis; cerebrospinal fluid; clinical research; cytokine receptors; diagnosis design /evaluation; enzyme linked immunosorbent assay; human old age (65+); human subject; interleukin 6; major depression; mental disorder diagnosis; neurofibrillary tangles; tau proteins

Tau protein is was found to be elevated in the cerebrospinal fluid (CSF) of patients with Alzheimer disease (AD), reflecting neurofibrillary tangle formation. CSF tau concentrations, when combined with age in a discriminant function analysis, increased the power to maker a correct diagnosis of AD in subjects less than 70 years old. Interleukin 6 (IL-6) contributes to the interaction between immune mechanisms and brain. CSF concentrations from geriatric patients with major depression showed significantly reduced levels of both IL-6 and the soluble Il-6 receptor (sIL-6R), measured by enzyme-linked immunosorbant assays (ELISA), compared with control CSF.

在阿尔茨海默病(AD)患者的脑脊液(CSF)中发现tau蛋白升高，反映神经原纤维的形成。在判别函数分析中，当脑脊液tau浓度与年龄相结合时，在70岁以下的受试者中，做出AD正确诊断的能力增加。白介素6(IL-6)参与免疫机制与脑之间的相互作用。用酶联免疫吸附试验(EL ISA)检测，老年抑郁症患者脑脊液中IL-6和可溶性IL-6受体(sIL-6R)水平明显低于对照组脑脊液。