NTP-CHEMICALS IN LABORATORY ANIMALS

实验动物中的 NTP 化学品

• 批准号: 6316176
• 负责人: WARD RICHTER
• 金额: --
• 依托单位: SOUTHERN RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-15 至 2003-03-01
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6316176
• 关键词: alkyl nitrile; carcinogen testing; dichloroacetate; imides; laboratory mouse; laboratory rat; oral administration; toxicant screening; transdermal drug delivery

The purpose of this contract is to conduct studies to evaluate the toxic and carcinogenic potential of selected chemicals by oral and dermal exposure. This project is divided into Tasks with all activities associated with a test chemical considered a Task. The Base Contract shall consist of Phase 1 (prestart activities) or Diisopropylcarbodiimide (Task 1), Methylene Blue (Task 2), Bromochloroacetic Acid (Task 3), Dibromoacetonitrile (Task 4), Dichloroacetic Acid (Task 5), and Bromodichloroacetic Acid (Task 6). During phase 1, the contractor shall perform those work activities associated with the determination of bulk chemical purity and identity, and validation of dose formulation/analysis methods, any health and safety concerns that must be addressed before study start, and only those other aspects specifically included in Phase 1.

该合同的目的是进行研究，以评估经口和皮肤接触某些化学品的毒性和致癌潜力。本项目分为多项任务，与试验化学品相关的所有活动均视为一项任务。基础合同应包括阶段1（预启动活动）或二异丙基碳二亚胺（任务1）、亚甲蓝（任务2）、溴氯乙酸（任务3）、二溴乙腈（任务4）、二氯乙酸（任务5）和溴二氯乙酸（任务6）。在第1阶段，承包商应执行与散装化学品纯度和身份的确定、剂量配制/分析方法的验证、研究开始前必须解决的任何健康和安全问题相关的工作活动，以及仅与第1阶段具体包括的其他方面相关的工作活动。