SYNTHESIS AND DISTRIBUTION OF OPIOID & RELATED PEPTIDES

阿片类药物的合成和分配

• 批准号: 6344332
• 负责人: Richard Allen Houghten
• 金额: $ 45.22万
• 依托单位: MIXTURE SCIENCES, INC.
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-08-01 至 2001-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6344332
• 关键词: chemical synthesis; drug design /synthesis /production; drug quality /standard; endogenous opioid; radiotracer

For nearly two decades, the National Institute on Drug Abuse and it's predecessor, Center for Studies of Narcotics and Drug Abuse, NIMH, has provided the scientific community working on problems of drug abuse with authentic, standardized supplies of controlled research drugs and chemicals. These include marijuana cigarettes, known hallucinogens, heroin, amphetamines, cannabinoids, and many other drugs essential for both clinical and laboratory -research studies. Recently, the isolation of Leu5-enkephalin, Met5-enkephalin, and other opioid peptides has generated an explosive interest in this research area. This active research area has generated the need for several opioid peptides and respective radiolabeled compounds in large guantities. The peptides are needed for a number of preclinical and clinical studies supported by NIDA--receptor-binding studies, evaluation of addiction and analgetic potential, pharmacokinetic studies, conformational studies by C.D.; N.M.R.; X-ray, laser-Raman, FT-IR, etc. Opioid peptides and their respective radiolabeled compounds are expensive and purity is not always sufficiently established. In order to meet the demand for pure, authentic compounds, NIDA plans to continue to maintain an inventory of about 10-15 peptides and their respective radiolabeled compounds for use in NIDA supported studies. Through this contract NIDA plans to continue to supply chemically pure, racemization-free peptides primarily to NIDA grantees and at the same time maintain capability to rapidly synthesize, on demand, new compounds that are potentially useful.

近二十年来，国家药物滥用研究所和它的 其前身为毒品和药物滥用研究中心，曾 为致力于药物滥用问题的科学界提供 真实、标准化的受控研究药物供应和 化学制品。其中包括大麻香烟，已知的致幻剂， 海洛因、安非他命、大麻素和许多其他毒品 包括临床和实验室研究。最近，与世隔绝 Leu5-脑啡肽、Met5-脑啡肽和其他阿片肽 在这一研究领域引起了爆炸性的兴趣。这是活动的 研究领域产生了对几种阿片肽和 相应的放射性标记化合物的数量很大。这些多肽是 支持的许多临床前和临床研究所需 NIDA--受体结合研究、成瘾评估和镇痛剂 潜力，药代动力学研究，构象研究由C.D. X-射线、激光拉曼、傅立叶变换红外光谱等研究阿片肽及其活性 每种放射性标记的化合物都很昂贵，而且纯度并不总是 已经足够确定了。为了满足对纯净品的需求， 正宗化合物，NIDA计划继续保持库存 约10-15个多肽及其各自的放射性标记化合物 在NIDA资助的研究中。通过这份合同，NIDA计划继续 主要向NIDA提供化学纯的、无外消旋的多肽 并同时保持快速合成的能力， 按需，潜在有用的新化合物。