课题基金 / 基金详情

CANCER FOLLOWING BONE MARROW TRANSPLANTATION

CANCER FOLLOWING BONE MARROW TRANSPLANTATION
骨髓移植后的癌症
批准号：
6294374
负责人：
H. JOACHIM DEEG
金额：
$0.48万
依托单位：
FRED HUTCHINSON CANCER RESEARCH CENTER
依托单位国家：
美国
项目类别：
财政年份：
1995
资助国家：
美国
项目状态：
未结题
起止时间：
1995-09-30 至
来源：
https://reporter.nih.gov/project-details/6294374
关键词：
age difference artificial immunosuppression autologous transplantation bone marrow transplantation cancer risk graft versus host disease human subject human therapy evaluation immunosuppressive neoplasm /cancer immunology radiation immunosuppression radiation related neoplasm /cancer whole body irradiation dosage

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中文摘要
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英文摘要
To evaluate the influence of immunosuppression and therapy with whole body irradiation and chemotherapy on the risk of new malignancies following bone marrow transplantation. The association between development of a new cancer, in particular, new solid tumors, and prolonged immune suppression from chronic GVHD and/or high dose radiation will be estimated. Cancer risk among the cohort of patients not exposed to immune suppression (autologous transplants) will be evaluated. Variation in risk by age at transplantation and time after transplantation will be quantified.
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