NATURAL HOST RESISTANCE TO SIVAGM INDUCED DISEASE

气质、冲动等方面的个体差异 社会行为的方方面面在人类身上很容易识别。是这样的 气质的差异可能与心理和心理因素有关 身体障碍、反社会行为和心脏病。一个数字 生理因素都是已知的相关因素。然而，最近 人们的注意力集中在单胺类神经递质上。 5-羟色胺、多巴胺和去甲肾上腺素。这样做的总体目标是 该项目是开发狒狒(Papio hamadryas s.l.)作为一个非人类 灵长类动物模型的神经化学和相关行为研究 个性气质。这里提出的两个近期目标 A)研究遗传变异在控制疾病发生中的作用 单胺类神经递质三种代谢物的表达 和b)评估两国之间的遗传和环境关系 这些单胺类代谢物和狒狒体内的各种行为。 这些遗传分析的结果将被用来形成假设 将在一个更大的项目中进行探索，该项目将调查 额外的行为和神经细胞表型的遗传力， 以及通过连锁和关联来定位相关基因 狒狒系谱的研究。

Individual differences in temperament, impulsivity and other aspects of social behavior are easily recognized in humans. Such differences in temperament may be related to psychological and physical disorders, antisocial behavior and heart disease. A number of physiologic factors are known to be relevant. However, recent attention has focused on the moncaminergic neurotransmitters serotonin, doparnine and norepinephrine. The general goal of this project is to develop the baboon (Papio hamadryas s.l.) as a nonhuman primate model for studies of neurochemistry and behavior related to individual temperament. The two immediate objectives proposed here are a) to investigate the role of genetic variation in controlling the expression of three metabolites of monoaminergic neurotransmitters, and b) to assess the genetic and environmental relationships among these monoamine metabolites and various behaviors in the baboon. Results of these genetic analyses will be used to formulate hypotheses to be explored in a larger project which will investigate the heritability of additional behavioral and neurochernical phenotypes, as well as map the relevant genes through linkage and association studies in baboon pedigrees.