PROPIONATE UTILIZATION, GLUCONEOGENESIS, & PYRUVATE RECYCLING IN HUMAN LIVER

丙酸利用、糖异生、

• 批准号: 6335264
• 负责人: ROLF GRUETTER
• 金额: $ 0.7万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-15 至 2001-08-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6335264
• 关键词: Mammalia; bioimaging /biomedical imaging; biomedical resource; human tissue; liver; magnetic resonance imaging; minerals; urinary tract

Dr. Bansal has recently moved to the University of Pennsylvania. Upon completion of several manuscripts which are in preparation, this subpoject will be deleted. We have implemented a three-dimensional 23Na MQ imaging sequence on the 4.7T system. This gradient echo imaging sequence is capable of collecting interleaved SQ and TQ 23Na images with very short echo times (2.5-5 ms). We have used this imaging sequence to study the effect of ischemia in rabbit kidney. Interleaved SQ and TQ filtered 23Na images were collected before and after sacrificing the animal with 32 x 32 x 64 data points over a 50 x 50 x 100 mm3 field of view and 4 ms echo time. The total image data collection time was 4 hours. The SQ image indicates a 4-5 fold greater signal intensity in the medullary region as compared to the cortex. The TQ filtered image of the normal kidney did not show any signal intensity due to the low sensitivity of the technique. However, on death, the renal cortex became clearly visible in the TQ filtered image without any substantial increase in signal intensity in the medullary region. This is mainly because the cortical region of the kidney has a large intracellular space while the medullary region is mainly intraluminal and vascular. These images clearly suggest that increase in MQ filtered signal intensity may be a very good marker of cellular injury. (Service 3) REPORT PERIOD: (09/01/97-08/31/98)

班萨尔博士最近搬到了宾夕法尼亚大学。