DNA, PROTEIN DNA COMPLEXES, ADSORPTION, LATERAL FORCE, BINDING ENERGY

DNA、蛋白质 DNA 复合物、吸附、横向力、结合能

• 批准号: 6326162
• 负责人: MARTIN GUTHOLD
• 金额: $ 6.76万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-05-15 至 2001-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6326162
• 关键词: biomedical resource; computers; technology /technique

GRINCH II, Direct Map Interpretation. In the early 1980s Tom Williams, while a member of the GRIP project, built the GRINCH system for the ab-initio interpretation of electron density maps. Williams' system was based on work by Drs. Jonathan Greer, Carroll Johnson, and Stanley Swanson for representing electron density by marking the ridges of high local density. At least 50 copies of this system were disseminated to the crystallographic community. Graduate student Juraj Horacek of the current GRIP project team was re-examining this ridge line approach to ab-initio electron density interpretation using new, more powerful ridge line finding mathematics developed in our department by David Eberly for the analysis of medical images. Our new approach is distinguished from prior work in that we do not simply connect critical points but actually trace the ridges of high density through an interpolated function. This should help us avoid some kinds of common errors in map interpretation. We expect this work to lead to both new representations for electron density and to new methodologies for its interpretation as a molecular structure. Horacek decided to abandon or postpone his Ph.D. work in order to enter Cornell Business School. He worked on the project from May until September. He may work on it again this summer. We shall see. We do not now expect another student to pick up this work; if not, this subproject will be abandoned.

Grinch II，直接地图解释。 在1980年代初期汤姆 威廉姆斯（Williams）是Grip项目的成员，建立了Grinch系统 用于电子密度图的Ab-Initio解释。 威廉姆斯 系统是基于Drs的工作。乔纳森·格里尔（Jonathan Greer），卡洛尔·约翰逊（Carroll Johnson）和 斯坦利·斯旺森（Stanley Swanson）代表电子密度 高局部密度的脊。 该系统的至少50份是 传播到晶体学界。 研究生 当前Grip项目团队的Juraj Horacek正在重新审视此事 脊线方法的Ab-Initio电子密度解释使用 新的，更强大的山脊线发现我们在我们的 David Eberly的部门用于分析医学图像。 我们的 新方法与先前的工作有区别，因为我们不仅仅是 连接关键点，但实际上追踪高密度的山脊 通过插值功能。 这应该帮助我们避免一些 地图解释中的常见错误。 我们希望这项工作能够 导致电子密度的新表示和新表示 解释为分子结构的方法论。 霍拉塞克决定放弃或推迟他的博士学位。为了工作 进入康奈尔商学院。 他从5月开始从事该项目 直到9月。 他可能会在今年夏天再次工作。 我们会看到的。 我们现在不希望另一个学生能够拿起这项工作。如果不， 该副本将被放弃。