CRYSTALLOGRAPHIC INVESTIGATIONS OF METAL ORGANIC NETWORK SOLIDS

两个涉及蛋白质结构测定的项目， 是药物设计目标描述。 蛋白质是 微粒体甘油三酯转移蛋白（MTP）和人 巨细胞病毒（HCMV）蛋白酶。 每个项目都涉及 利用三维结构信息辅助设计 新的治疗剂。 在每种情况下，目标都是抑制 新的蛋白质靶点 这些结构项目中的每一个都呈现出 需要使用高亮度的特殊挑战 用于数据收集的同步辐射源。 在MTP的情况下， 晶体中天然和衍生数据的分辨率限制 必须延伸该大蛋白质（150 kDa）以解析结构。 在HCMV蛋白酶的情况下，其中两种有用的衍生物已经被发现。 已确定，分离度限值（沿着c* 有利）必须 在反射领域的其余部分进行扩展，以便 制作一张可解读的地图

Two projects involving structure determinations of proteins that are drug design targets are described. The proteins are the microsomal triglyceride transfer protein (MTP), and human cytomegalovirus (HCMV) protease. Each of these projects involves the use of three-dimensional structural information to aid in the design of new therapeutic agents. In each case, the goal is to inhibit a novel protein target. Each of these structures projects presents special challenges that require the use of a high brilliance synchrotron radiation source for data collection. In the case of MTP, limits of resolution of native and derivative data from crystals of this large protein (150 kDa) must be extended to solve the structure. In the case of HCMV protease, where two useful derivatives have been identified, limits of resolution, which are favorable along c*, must be extended in the rest of the sphere of reflection in order to produce an interpretable map.