ROLE OF NITRIC OXIDE IN FERTILIZATION

一氧化氮在受精中的作用

• 批准号: 6351424
• 负责人: DAVID EPEL
• 金额: $ 20.96万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-02-01 至 2003-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6351424
• 关键词: acrosome; calcium flux; early embryonic stage; egg /ovum; enzyme activity; fertilization; nitric oxide; nitric oxide synthase; sperm; sperm motility; tissue /cell culture

DESCRIPTION (adapted from the applicant's abstract): The goal of this study is to determine the roles of nitric oxide (NO) and its possible relationship with the intracellular Ca2+ transients in the processes of oocyte activation and cell cycle. The possible role of NO in regulating the egg's ion channels (as part of polyspermy block) and sperm physiology (such as motility and the acrosome reaction) will also be investigated.

描述（改编自申请人的摘要）：本研究的目标是 确定一氧化氮 (NO) 的作用及其与 卵母细胞激活过程中的细胞内 Ca2+ 瞬变 细胞周期。 NO 在调节卵子离子通道中的可能作用（如 多精块的一部分）和精子生理学（例如活力和 顶体反应）也将被研究。