CORE--CELL AND MOLECULAR BIOLOGY FACILITY

在预料到技术的革命性影响的情况下 分子生物学对糖尿病研究的影响，密歇根大学 糖尿病研究和培训中心(MDRTC)提出了一种分子 生物核心公司(MBC)向其研究人员介绍这些技术 作为其1986年竞争续签申请的一部分。因为 相关研究基地刚刚建立，与 生殖与发育生物学中心应运而生。 研究基础薄弱，以及对联合 监督导致核心不赞成，强烈告诫 用于随后重新制定的补充申请。这样的一种 NIDDKD提交了申请并批准了资助 委员会在1988年初提出的，但为 糖尿病中心导致该提案的行政撤回。一个 随后配备并启动了核心的缩小版 利用机构资金，为多个中心的进入提供便利 分子领域的调查人员。戏剧性的分子输注 在过去五年中进入糖尿病中心研究基地的技术 几年来，加上最近招聘的杰克·迪克森博士，一位杰出的 糖尿病相关分子生物学家在指导 糖尿病中心分子生物学核心，充分证明发起 一个全面的分子生物学核心，以增强糖尿病和内分泌- 通过提供符合成本效益的方式在该中心进行相关的分子研究 加强调查人员研究活动的方法，包括 引进和利用现代分子技术，通过促进 协作，并提供最先进的方法和培训 分子生物学领域的研究人员，通过提供 也是分析分子结构和功能的基础 产生研究基因调控所需的工具，并通过 提供疾病标志物以加深对疾病的认识和治疗 糖尿病及其并发症和相关内分泌代谢的研究进展 精神错乱。

In anticipation of the revolutionary impact that the techniques of molecular biology would have on diabetes research, the Michigan Diabetes Research and Training Center (MDRTC) proposed a Molecular Biology Core (MBC) to introduce these techniques to its investigators as part of its 1986 Competing Renewal Application. Because the relevant research base was just being established, a joint core with the Center for Reproductive and Developmental Biology was proposed. Weakness of the research base, and administrative concerns about joint supervision led to disapproval of the core, with a strong admonition for a subsequent reformulated supplemental application. Such an application was submitted and approved for funding by the NIDDKD Council in early 1988, but the institution of a funding "cap" for the Diabetes Center led to administrative withdrawal of the proposal. A scaled-down version of the Core was subsequently equipped and initiated with institutional funds, facilitating the entry of several Center investigators into the molecular realm. Dramatic infusion of molecular techniques into the Diabetes Center research base over the last five years, plus the recent recruitment of Jack Dixon, PhD, an outstanding diabetes-related molecular biologist experienced in directing a Diabetes Center Molecular Biology Core, full justify the initiation of a full-scale Molecular Biology Core to enhance diabetes and endocrine- related molecular research at the Center by providing cost-effective methods for enhancing research activities among investigators, by introducing and exploiting modern molecular techniques, by fostering collaboration and providing state-of-the-art methods and training to investigators in the area of molecular biology, by providing the foundation for analysis of molecular structures and function as well as generating the tools necessary to study gene regulation, and by providing disease markers to further the understanding and treatment of diabetes, its complications and related endocrine and metabolic disorders.