MOLECULARLY ENGINEERED STEALTH SURFACES

通过表面锚定肽或蛋白质的特异性信号传导 建议开发表面涂层， 背景，锚定触发分子或 识别位点，使得它们可接近细胞受体。 而不是剪裁上的识别位点之间的固定距离， 具体的模型表面，我们希望细胞重新排列 触发分子以满足其需要，就像自然界中经常发生的那样。 的 该项目的目标是开发模型系统， 识别位点被固定在一个隐形矩阵中， 横向。 ESCA和西姆斯被用来表征 制备的表面。

Specific signalling via surface-anchored peptides or proteins suggests the development of surface coatings which act as stealth backgrounds, anchoring the trigger molecules or clusters of recognition sites such that they are accessible to cell receptors. Rather than tailoring fixed distances between recognition sites on a specific model surface, we would like the cell to rearrange the trigger molecules to their needs, as occurs regularly in nature. The goal of this project is to develop model systems in which the recognition sites are anchored in a stealth matrix yet can move laterally. ESCA and SIMS are being used to characterize the as-prepared surfaces.