INTERACTION OF MELANIN W/ FREE RADICALS

黑色素与自由基的相互作用

• 批准号: 6307902
• 负责人: TADEUSZ SARNA
• 金额: $ 1.13万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-03-01 至 2001-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6307902
• 关键词: bioengineering /biomedical engineering; biological products; biomaterials; biomedical resource

Although it is generally believed that one of the major biological functions of melanin is photoprotection, its molecular mechanism is not fully understood. Thus it can be argued that besides simple light screening, melanin exerts its photoprotective action via sequestration of heavy metal ions and scavenging of reactive free radicals. Of course, the ability of melanin to scavenge free radicals is likely to depend on their physicochemical properties: their lifetime, one-electron reduction potential, and net charge. We studied the interaction of two synthetic polymers, dopa melanin (DM) and cysteinyldopa melanin (CDM), with a series of reducing and oxidizing free radicals. Our data indicate that melanin can act as a powerful scavenger both for oxidizing and reducing radicals.

尽管人们普遍认为， 黑色素的功能是光保护，其分子机制是 没有完全理解。 因此，可以说，除了简单的光， 筛选，黑色素通过螯合作用发挥其光保护作用 重金属离子和清除活性自由基。 的 当然，黑色素抑制自由基的能力很可能 取决于它们的物理化学性质：它们的寿命， 单电子还原电位和净电荷。 我们研究了 两种合成聚合物多巴黑色素（DM）和 半胱氨酰多巴黑色素（CDM），具有一系列的还原和氧化 自由基 我们的数据表明，黑色素可以作为一种强大的 用于氧化和还原自由基的清除剂。