TRANSFER OF TECHNOLOGY FOR DEVELOPMENT & APPLICATIONS OF IN VIVO EPR

已经知道了一段时间了，不同的地区 大脑有不同的氧分压。我们还知道，不同的 大脑的宏观区域对 缺氧/缺血。然而，目前尚不清楚 氧合作用与对缺氧/缺血的耐受有关。我们是 应用特定部位植入的LiPc评估脑内局部氧分压 麻醉大鼠。然后，动物处于分级缺氧状态 协议。比较了常氧和低氧条件下脑组织的氧分压。 被评估的区域是皮质、海马体和基底节， 已知具有不同耐缺氧能力的地区。

It has been known for some time that different regions of the brain have different oxygen tensions. It is also known that different macroscopic regions of the brain exhibit differing tolerances to hypoxia/ischemia. However, it is not known if the variation in oxygenation correlates with tolerance to hypoxia/ishemia. We are assessing regional brain pO2 using LiPc implanted at specific sites in anesthetized rats. The animal is then subjected to a graded hypoxia protocol. Normoxic and hypoxic pO2 values in the brain are compared. The regions being assessed are cortex, hippocampus and basal ganglia, regions which are known to have differing hypoxia tolerances.