A novel nitric oxide-based treatment for recalcitrant Staphylococcus aureus-associated chronic rhinosinusitis

一种基于一氧化氮的新型治疗顽固性金黄色葡萄球菌相关慢性鼻鼻窦炎的方法

• 批准号: nhmrc : 1047576
• 负责人: A/Pr Sarah Vreugde
• 金额: $ 36.1万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/novel-nitric-oxide-chronic-rhinosinusitis/111948
• 关键词: novel; nitric; oxide; based; treatment

Chronic rhinosinusitis (CRS) is a common condition affecting the lives of up to 16% of the population. With yet no cure, the search for effective means of therapy is crucial. Patients with severe disease are most often found to have infection with the bacteria Staphylococcus aureus, associated with more severe symptoms and reduced quality of life. This study will investigate the effectiveness of a novel topical liposome-encapsulated nitric oxide in the treatment of this burdensome disease.

慢性鼻窦炎（CRS）是一种常见病，影响着多达16%的人口的生活。由于目前还没有治愈方法，寻找有效的治疗方法至关重要。重症患者最常被发现感染金黄色葡萄球菌，伴有更严重的症状和生活质量下降。本研究将探讨一种新型外用脂质体包裹的一氧化氮在治疗这种繁重疾病中的有效性。