DEVELOPMENT OF CCD-BASED X-RAY DETECTOR SYSTEMS FOR STRUCT BIOL & MED IMAGING

基于 CCD 的结构生物学 X 射线检测器系统的开发

• 批准号: 6310152
• 负责人: WALTER PHILLIPS
• 金额: $ 3.26万
• 依托单位: BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-01 至 2000-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6310152
• 关键词: bioimaging /biomedical imaging; biological products; biomedical equipment development; biomedical resource; radiography; radiology; structural biology; technology /technique

We are a I 0-member group at Brandeis focused on developing and describing state-of-the-art x-ray detectors for applications in structural biology and medical imaging. This involves the design and fabrication of hardware, electronics, and software for data-collection and data-processing. Design criteria include: (1) a large area, (2) fast readout, (3) large dynamic range and (4) high spatial resolution. A four-module detector is under construction for the NSLS, to be used at beamlines X25 and X12-C. Objectives: This system will be installed during the first grant year. This detector will be characterized and improvements will be sought to the engineering of the detector, the readout logic and electronics, and, in cooperation with the software development project (9.c. 1. 1), integration with beamline and data-collection software. After the 4-module detector project is finished, we expect to continue development of CCD-based detectors in two areas that we believe offer exciting possibilities: (1) detectors with considerably faster readout for time-resolved and Laue-diffraction investigations, and (2) detectors based on large-area CCDs.

我们是布兰迪斯的一个10人小组，专注于开发和 描述了用于以下应用的现有技术的X射线检测器 结构生物学和医学成像。 这涉及到设计和 用于数据收集的硬件、电子设备和软件的制造 和数据处理。 设计标准包括：（1）面积大，（2） 读出速度快，（3）动态范围大，（4）空间分辨率高。 目前正在为NSLS建造一个四模块探测器， 在光束线X25和X12-C处。 目标：该系统将在第一次拨款期间安装 年 该探测器的特点和改进将是 寻求探测器的工程，读出逻辑和 电子，并与软件开发项目合作， （9.c. 1. 1）、与光束线和数据采集软件的集成。 在4模块探测器项目完成后，我们预计将继续 在两个领域开发基于CCD的探测器，我们相信 令人兴奋的可能性：（1）探测器具有相当快的速度 用于时间分辨和劳厄衍射研究的读出，以及（2） 基于大面积CCD的探测器。