TRIDENT

三叉戟

• 批准号: 6291662
• 负责人: A RICHARD CHAMBERLIN
• 金额: $ 45.09万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-01 至 2003-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6291662
• 关键词: biomedical automation; biomedical equipment purchase; chemical synthesis; combinatorial chemistry; peptide chemical synthesis; peptide library

Support for the purchase of an Argonaut(TM) Trident parallel synthesis instrument is requested. There currently is no significant capability of automated parallel synthesis available to synthetic chemists at UCI, and research productivity on a number of NIH-funded projects would be enhanced dramatically by the acquisition of such an instrument. The requested Trident would serve as the cornerstone of a larger core facility at UCI, which is being established in order to make state-of-the-art parallel synthesis equipment available to UCI researchers for the first time. Research projects of the major users that would explicitly benefit from the purchase of this instrument include: (a) Chamberlin, memory enhancers, potassium channel blockers, and selective inhibitors of protein phosphatases; (b) Feher, novel dendritic compounds with peptidic and carbohydrate functionalities on a silsesquioxane core; (c) Nowick, artificial beta-sheets as models for protein structure; (d) Overman, guanidine-containing alkaloids and intramolecular Heck reaction development; (e) Rychnovsky, anticancer tetrahydrofurans; (f) Shea, bioreceptor mimics via molecular imprinting; (g) Van Vranken, ditryptophan- and dityrosine-crosslinked peptides; and (h) Woerpel, new reactions of silacyclopropanes. Aside from the major user group there are many other NIH funded research groups who will make use of the facility. The nature of the instrument to be purchased is such that it can be most effectively run by, or under the supervision of, an experienced operator; therefore, an important component of this request is a commitment by the UCI School of Physical Sciences of a new PhD level staff position to oversee the facility operations. UCI provides long-term major funding for a number of thriving instrumentation facilities that support the research faculty in Chemistry, including NMR, mass spectroscopy, molecular modeling, Xray, electronics, and laser/spectroscopy facilities. Currently the annual commitment is over $500,000 to these facilities in eight salaries and operational support. Additional operational funding is obtained though charges to the grants and contracts of the user community. The parallel synthesis facility, in which the requested Trident(TM) will reside, will follow this very successful model.

要求购买Argonaut（TM）三叉戟并行合成工具。目前，在UCI的合成化学家可用的自动平行合成尚无明显的能力，并且对许多NIH资助的项目的研究生产力将通过获取这种仪器而大大增强。所请求的Trident将作为UCI较大核心设施的基石，为了使UCI研究人员首次使用最新的并行合成设备。主要用户的研究项目将从购买该工具中明确受益的主要用户包括：（a）Chamberlin，记忆增强剂，钾通道阻滞剂和蛋白质磷酸酶的选择性抑制剂； （b）Feher，具有肽和碳水化合物功能的新型树突状化合物在Silsesquioxane核心上； （c）Nowick，人工β表作为蛋白质结构的模型； （d）含鸟嘌呤的生物碱和分子内heck反应的发育； （e）Rychnovsky，抗癌四氢呋喃； （f）乳木果，生物感受器通过分子印刷模仿； （g）范·弗兰肯（van Vranken），二硝基和丁乙糖固定肽； （h）woerpel，硅烷丙烷的新反应。除了主要用户组外，还有许多其他由NIH资助的研究小组使用该设施。要购买的工具的性质是这样，它可以最有效地由经验丰富的操作员的监督或在监督下运行；因此，该请求的一个重要组成部分是UCI物理科学学院的承诺，以新的博士学位员工职位负责监督设施运营。 UCI为支持化学研究学院的许多繁荣的仪器设施提供了长期的主要资金，包括NMR，质谱，分子建模，XRAY，电子学和激光/光谱设施。目前，年度承诺超过500,000美元，以八项薪水和运营支持。通过向用户社区的赠款和合同收取的费用，获得了其他运营资金。所请求的三叉戟（TM）将居住的并行合成设施将遵循此非常成功的模型。