TRIDENT

请求为购买ArgAert(TM)三叉戟并行合成仪器提供支持。目前，UCI的合成化学家还没有显著的自动平行合成能力，而NIH资助的一些项目的研究生产率将通过获得这样的仪器而显著提高。所要求的三叉戟将作为UCI一个更大的核心设施的基石，该设施正在建立，目的是向UCI的研究人员首次提供最先进的并行合成设备。将明确受益于购买该仪器的主要用户的研究项目包括：(A)Chamberlin、记忆增强剂、钾通道阻滞剂和蛋白磷酸酶选择性抑制剂；(B)FEHER，在倍半硅氧烷核心上具有肽和碳水化合物功能的新型树枝状化合物；(C)作为蛋白质结构模型的Nowick人工β-折叠；(D)Overman，含胍的生物碱和分子内Heck反应进展；(E)Rychnovsky，抗癌四氢呋喃；(F)Shea，通过分子印迹模拟生物受体；(G)Van Vranken，双隐氨酸和dityroine交联肽；和(H)沃尔佩尔，硅环丙烷的新反应。除了主要的用户群体，还有许多其他由美国国立卫生研究院资助的研究团体将使用该设施。要购买的仪器的性质是，它可以由经验丰富的操作员最有效地运行或在其监督下运行；因此，这一请求的一个重要组成部分是UCI物理科学学院承诺设立一个新的博士级别的工作人员职位，以监督设施的运营。UCI为许多蓬勃发展的仪器设施提供长期的主要资金，这些设施支持化学方面的研究人员，包括核磁共振、质谱学、分子建模、X射线、电子学和激光/光谱分析设施。目前，每年对这些设施的8项薪金和业务支助承诺超过500 000美元。通过向用户社区的赠款和合同收取费用，可获得额外的业务资金。被请求的三叉戟(商标)将驻留的平行合成设施将遵循这一非常成功的模式。

Support for the purchase of an Argonaut(TM) Trident parallel synthesis instrument is requested. There currently is no significant capability of automated parallel synthesis available to synthetic chemists at UCI, and research productivity on a number of NIH-funded projects would be enhanced dramatically by the acquisition of such an instrument. The requested Trident would serve as the cornerstone of a larger core facility at UCI, which is being established in order to make state-of-the-art parallel synthesis equipment available to UCI researchers for the first time. Research projects of the major users that would explicitly benefit from the purchase of this instrument include: (a) Chamberlin, memory enhancers, potassium channel blockers, and selective inhibitors of protein phosphatases; (b) Feher, novel dendritic compounds with peptidic and carbohydrate functionalities on a silsesquioxane core; (c) Nowick, artificial beta-sheets as models for protein structure; (d) Overman, guanidine-containing alkaloids and intramolecular Heck reaction development; (e) Rychnovsky, anticancer tetrahydrofurans; (f) Shea, bioreceptor mimics via molecular imprinting; (g) Van Vranken, ditryptophan- and dityrosine-crosslinked peptides; and (h) Woerpel, new reactions of silacyclopropanes. Aside from the major user group there are many other NIH funded research groups who will make use of the facility. The nature of the instrument to be purchased is such that it can be most effectively run by, or under the supervision of, an experienced operator; therefore, an important component of this request is a commitment by the UCI School of Physical Sciences of a new PhD level staff position to oversee the facility operations. UCI provides long-term major funding for a number of thriving instrumentation facilities that support the research faculty in Chemistry, including NMR, mass spectroscopy, molecular modeling, Xray, electronics, and laser/spectroscopy facilities. Currently the annual commitment is over $500,000 to these facilities in eight salaries and operational support. Additional operational funding is obtained though charges to the grants and contracts of the user community. The parallel synthesis facility, in which the requested Trident(TM) will reside, will follow this very successful model.