A novel strategy for targeting castrate-resistant prostate cancer

针对去势抵抗性前列腺癌的新策略

• 批准号: nhmrc : 1138242
• 负责人: A/Pr Arun Azad
• 金额: $ 54.05万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/novel-strategy-targeting-prostate-cancer/1318696
• 关键词: novel; strategy; targeting; castrate; resistant

Modern drugs for advanced prostate cancer are based on starving the tumour of hormones. However, tumours either escape this treatment or are inherently resistant to it. We have developed a new approach with drugs that block protein synthesis. This deprives tumours of the building blocks to make new cancer cells. In this project, we will determine the effectiveness of this new treatment on samples of patient prostate cancer tissue that have failed currently available drugs.

治疗晚期前列腺癌的现代药物是基于饥饿肿瘤的激素。然而，肿瘤要么逃避这种治疗，要么天生就对它有抵抗力。我们已经开发出一种新的方法，用药物阻断蛋白质合成。这就剥夺了肿瘤制造新的癌细胞的基石。在这个项目中，我们将确定这种新疗法对目前可用药物失败的患者前列腺癌组织样本的有效性。