A novel strategy targeting quorum sensing molecules and catalase function to block Pseudomonas aeruginosa lung infection

一种针对群体感应分子和过氧化氢酶功能阻断铜绿假单胞菌肺部感染的新策略

• 批准号: nhmrc : 529309
• 负责人: A/Pr Margaret Cooley
• 金额: $ 30.08万
• 依托单位: Central Queensland University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/novel-strategy-targeting-lung-infection/99713
• 关键词: novel; strategy; targeting; quorum; sensing

Pseudomonas aeruginosa causes serious infections, particularly in those with Cystic Fibrosis, immunocompromise, serious burns or long term catheters. We will use a unique strategy to target virulence factors that will assist in clearing acute infection, prevent establishment of new chronic infections, and potentially reduce severity of established chronic infections. It has the potential to make antibiotic therapy more effective and lessen the extent of antibiotic therapy required.

铜绿假单胞菌引起严重感染，特别是在囊性纤维化，免疫功能低下，严重烧伤或长期导管的患者中。我们将使用一种独特的策略来靶向毒力因子，这将有助于清除急性感染，防止建立新的慢性感染，并可能降低已建立的慢性感染的严重程度。它有可能使抗生素治疗更有效，并减少所需抗生素治疗的程度。