MENTORED MEDICAL STUDENT CLINCAL RESEARCH PROGRM

描述（改编自申请人的摘要）：申请人的目标 对于这个MMSCRP是获得深入接触学术临床 研究，并开始获得必要的技能，在病人的职业生涯- 导向研究。 此外，具体考察的项目将 允许申请人在研究中应用严格的科学方法 对没有反应的临床问题的补充医学治疗 与传统疗法相比。 申请人将获得结构化 在研究的所有阶段进行指导，包括招募患者， 进行研究测试、数据组织、分析、解释， 演示文稿. 申请人的教育计划将提供严格的 在为期一年的课程，其中将涵盖成果研究和 临床流行病学、研究设计、生物统计学方法和分析， 临床试验的开展、临床试验中的伦理问题和健康 服务研究。 除了正式的课程，申请人将 积极参与大学的方案审查和讨论 机构审查委员会。 最后，申请人将充分参与 定期安排的大会、会议和议定书审查 综合临床研究中心（GCRC）。 临床研究将是一项 前瞻性、随机、双盲、安慰剂对照试验，以确定 如果一种草药制剂，帕德玛基本，改善患者的功能， 症状性PVOD治疗16周。 研究的主要终点是 最大步行距离 次要终点将包括：1）无痛 2）血流介导的内皮依赖性前臂血管舒张; 3)静息和运动后踝/肱指数和动脉波形; 4)血压、血清脂质和凝血特征;以及5）患者良好- 根据SF-36确定的健康和生活质量功能自我评估 和行走障碍测试仪 MMSCRP将为申请人提供 有机会联合收割机结合广泛的课堂和研讨会课程 在临床研究与一个项目发起的学生，其中她 将在临床研究的所有阶段具有直接经验 包括研究设计、数据采集、分析和演示。 是 预计这将巩固在以下方面获得的信息和技能： 以前的培训，将是在病人为基础的职业生涯的第一步 调查

DESCRIPTION (Adapted from the applicant's abstract): The applicant's goals for this MMSCRP are to obtain an in-depth exposure to academic clinical research and to begin to acquire the skills necessary for a career in patient- oriented research. In addition, the specific project to be investigated will allow the applicant to apply rigorous scientific methods in the study of a complementary medical therapy for a clinical problem which does not respond well to conventional therapies. The applicant will receive structured mentoring at all stages of the study, including recruitment of patients, performance of study tests, data organization, analysis, interpretation, and presentation. The applicant's educational plan will provide rigorous coursework in a one-year program which will cover outcomes research and clinical epidemiology, study design, biostatistical methods and analysis, conduct of clinical trials, ethical issues in clinical trials, and health services research. In addition to formal coursework, the applicant will actively participate in protocol review and discussions in the University's Institutional Review Board. Finally, the applicant will fully participate in regularly scheduled conferences, meetings, and reviews of protocols in the General Clinical Research Center (GCRC). The clinical study will be a prospective, randomized, double-blind, placebo-controlled trial to determine if a herbal preparation, Padma Basic, improves function in patients with symptomatic PVOD treated for 16 weeks. The primary endpoint of the study is maximal walking distance. Secondary endpoints will include: 1) pain-free walking distance; 2) flow-mediated endothelium-dependent forearm vasodilation; 3) resting and post-exercise ankle/brachial indices and arterial waveforms; 4) blood pressure, serum lipid and coagulation profiles; and 5) patient well- being and quality of life self-assessment of function as determined by SF-36 and Walking Impairment Questionnaires. The MMSCRP would provide the applicant with the opportunity to combine an extensive classroom and seminar curriculum in clinical research with a project initiated by the student, in which she will have direct experience in all phases of the conduct of a clinical study including study design, data acquisition, analysis, and presentation. It is expected that this will consolidate information and skills acquired in previous training and will be the first step in a career in patient-based investigation.