SPORE IN BREAST CANCER

这个SCORE申请是根据国家癌症研究所的RFA提交的，将利用Robert H. Lurie综合癌症中心在乳腺癌研究和治疗方面的优势。SPORE将提供基础设施，将基础科学家和临床医生聚集在一起，快速测试人类乳腺癌预防、早期检测、诊断和治疗的新方法。《孢子》的具体主题是：1；探讨饮食和激素在乳腺癌发生中的作用。2. 目的：研究乳腺癌的细胞和分子生物学。3. 评估与乳腺癌风险及预防相关的因素。4. 实施创新的乳腺癌转化疗法。《孢子》申请包括六个主要研究项目、三个职业发展项目、五个试点项目和四个支持研究的核心设施。主要研究项目有：#1。抗雌激素药物耐药性（PI Jordan），排名第二。雌激素激动剂和拮抗剂通过非经典转录途径的作用（PI Jameson）， #3，转基因小鼠乳腺癌发生的饮食和激素改变（PI Thor）， #4。乳腺液，唾液和血清样本中的雌二醇水平（PI查特顿），#5。抗雌激素和乳腺密度和绝经前妇女（PI Morrow）， #6血管抑制剂治疗乳腺癌：一项转化研究（PI Soff）。核心设施包括：行政、组织资源、临床和生物统计中心。被选为SPORE项目一部分的研究人员来自不同的学科，从临床项目到化学工程、病理学和微生物免疫学。为了保持调查员之间有意义的沟通，我们将每月召开SPORE调查员会议，每年召开一次务虚会，每月召开一次执行委员会会议，每位调查员除了自己的项目外，还将积极参与至少一个项目（或核心）。基于所描述的基础设施，我们庞大的患者群体和我们的生产力记录，我们相信罗伯特H. Lurie综合癌症中心非常适合SPORE项目。

This SCORE application submitted in response to the RFA from National Cancer Institute, will take advantage of the strengths in breast cancer research and treatment that exist at the Robert H. Lurie Comprehensive Cancer Center. The SPORE will provide the infrastructure to bring together basic scientists and clinicians to rapidly test new approaches in the prevention, early detection, diagnosis and treatment of human breast cancer. The specific themes of the SPORE are: 1. To investigate the role of diet and hormones in breast carcinogenesis. 2. To study the cell and molecular biology of breast cancer. 3. To evaluate factors associated with breast cancer risk and prevention. 4. To implement innovative translational therapies for breast cancer. The SPORE application consists of six principal research projects, three career development projects, five pilot projects and four Core facilities to support the research. The principal research projects are: #1. Drug resistance to anti-estrogens (PI Jordan), #2. Actions of estrogen agonists and antagonists by non-classical transcription pathways (PI Jameson), #3, Dietary and hormonal modifications of breast carcinogenesis in transgenic mice (PI Thor), #4. Estradiol levels in breast fluid, saliva and serum samples (PI Chatterton), #5. Anti-estrogens and breast density and pre-menopausal women (PI Morrow), #6 Angiostatic therapy for breast cancer: a translational study (PI Soff). The Core facilities include: Administration,, Tissue Resources, Clinical and Biostatistical Cores. The investigators selected to be part of the SPORE Program come from a variety of disciplines ranging from Clinical Programs to Chemical Engineering, Pathology and Microbiology-Immunology. To maintain meaningful communication between investigators, we will have monthly meetings of SPORE investigators, an annual retreat, monthly meetings of the Executive Committee and each investigator will be actively involved with at least one project (or core) in addition to their own. Based on the infrastructure described, our large patient population and our track record of productivity, we believe that the Robert H. Lurie Comprehensive Cancer Center is well suited for the SPORE program.