CONCURRENT ETHANOL AND COCAINE WITHDRAWAL--NEUROPSYCHOLOGICAL STUDY

有慢性精神分裂症病史的患者急性戒酒 众所周知，依赖会导致一种综合征，这种综合征在其 演示文稿。中枢神经系统与戒酒有关 已经被研究过了。然而，大多数研究都集中在&gt；35 有有限或未指明的其他药物病史的一岁患者 虐待。因此，我们对中枢神经系统的影响知之甚少 酒精戒断与其他药物戒断相结合所致，或 患有医学(营养不良)或精神疾病(反社会人格) 经常伴随着其他药物滥用的变数。这样的知识是 在向门诊发展的背景下尤其相关 戒毒和关于这些人的能力的悬而未决的问题 让患者同时在家中或在工作中安全地执行任务 正在戒酒/戒毒。在这项研究中，我们建议比较 150例酒精中毒患者的神经生理和神经心理状态 伴有或不伴有可卡因的依赖患者(n=75) 依赖。一组非药物依赖的受试者(n=35)将接受测试 作为对照。评估小组将包括静息脑电的测量 活动、感觉功能、运动功能、视觉和听觉 选择性注意力和短期记忆。添加剂和/或 维生素缺乏与反社会人格的交互作用 无序性也将被评估。主要的假设是 同时戒除酒精和可卡因依赖的患者 将以脑电特定指标的表现受损为特征 活动、运动和感觉功能。

The acute withdrawal of alcohol from patients with histories of chronic dependence is known to precipitate a syndrome that is variable in its presentation. The central nervous system correlates of alcohol withdrawal have been studied previously. However, most studies have focused on >35 year old patients with limited or unspecified histories of other drug abuse. We therefore have little understanding of the CNS effects that result from combining alcohol withdrawal with other drug withdrawal, or with medical (malnutrition) or psychiatric (antisocial personality) variables that frequently accompany other drug abuse. Such knowledge is particularly relevant in the context of the movement toward outpatient detoxification and unanswered questions regarding the abilities of such patients to safely perform tasks at home or at work while simultaneously undergoing alcohol/drug withdrawal. In this study, we propose to compare the neurophysiological and neuropsychological status of 150 alcohol dependent patients with (n=75) or without (n=75) co-morbid cocaine dependence. A group of non drug-dependent subjects (n=35) will be tested as a control. The assessment battery will include measures of resting EEG activity, sensory functioning, motor functioning, visual and auditory selective attention, and short term memory. The additive and/or interactive effects of vitamin deficiency and antisocial personality disorder will also be evaluated. The principal hypothesis states that patients concurrently withdrawing from both alcohol and cocaine dependence will be characterized by impaired performance on specific measures of EEG activity, and motor and sensory function.