LONG-TERM FUNCTIONING AND ALCOHOL TREATMENT--LAPSE AND RELAPSE IN ADOLESCENTS

该研究项目组成部分的长期目标是开发 预防和减少复吸问题的有效方法 改变了他们的药物滥用的青少年。该项目有四个 具体目标：(1)描述长期*最多5年)酒精(和 其他毒品)使用和其他心理社会功能(例如，教育、使用 自由、时间、同伴关系)在当前和新的PAARC领域 临床样本；(2)评估建议的变异的充分性 根据成人文献改编的治疗结果模型 对其他领域的物质使用和长期运作的解释， 以及在PAARC临床中对复发的经验性定义 样本；(3)在新的临床样本中研究即刻 在以下情况下，酒精或其他药物使用的沉淀物失效/复发 人、治疗和环境决定因素；和(4)进行 新临床样本中失误和复发的事件史分析。 受试者将是来自当前和新的PAARC临床的男性和女性 在基线上符合DSM-IV当前酒精滥用标准的样本或 依赖性诊断。据估计，中国有162、150和150名青少年 相同数量的男性和女性将符合纳入 这个项目来自目前的PAARC队列，将完成1-，3-， 分别进行5年的随访评估。的对应编号 新的临床队列分别为130人和60人，用于1年和3年的随访。 在适当的情况下，与性别和年龄匹配的社区控制也将是 从临床核心采集的样本用于分析。除了……之外 标准的PAARC评估方案，新的队列受试者 组件将完成实现此目标所需的其他措施。 项目的具体目标。此外，本研究的新的临床队列受试者 研究将在前12个月进行每月电话采访 几个月后的基线，重点是日常酒精和其他药物的使用， 治疗活动和复发诱因。数据分析将包括 描述性统计，使用单变量和 多变量检验、通径分析和事件历史分析。

The long-term goal of this research project component is to develop effective methods of preventing and reducing the problem of relapse in adolescents who have modified their substance abuse. The project has four specific aims: (1) To describe long-term *up to 5 years) alcohol (and other drug) use and other psychosocial functioning (e.g., education, use of free, time, peer relationships) areas in the current and new PAARC clinical samples; (2) To evaluate the adequacy of a variant of a proposed model of outcome following treatment adapted from the adult literature for the explanation of substance use and long-term functioning in other areas, and of empirically derived definitions of relapse in the PAARC clinical samples; (3) To study in the new clinical sample the immediate precipitant of alcohol or other drug use lapses/relapses, in the context of person, treatment, and environmental determinants; and (4) To conduct event history analyses of lapses and relapses in the new clinical sample. Subjects will be males and females from the current and new PAARC clinical samples who at baseline meet criteria for DSM-IV current alcohol abuse or dependence diagnosis. It is estimated that 162, 150, and 150 adolescent in equal numbers of males and females will have met criteria for inclusion in this project from the current PAARC cohort and will have completed 1-,3-, and 5-year follow-up assessments, respectively. Counterpart numbers for the new clinical cohort are 130 and 60 for the 1- and 3-year follow-ups. Where relevant, gender- and age-matched community controls also will be sampled from the clinical core for purposes of analysis. In addition to the standard PAARC assessment protocol, new cohort subjects in this component will complete additional measures required to achieve this project's specific aim. In addition, new cohort clinical subjects in this study will be administered monthly telephone interviews for the first 12 months post baseline that focus on daily alcohol and other drug use, treatment activities, and relapse precipitants. Data analyses will include descriptive statistics, comparison of group means by use of univariate and multivariate tests, path analysis, and event history analyses.