HIV RELATED ORAL LESION IN THE ERA OF HAART

HAART 时代的 HIV 相关口腔病变

• 批准号: 6205206
• 负责人: JOAN F HILTON
• 金额: $ 19.04万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-04-01 至 2005-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6205206
• 关键词: AIDS therapy; HIV infections; adolescence (12-20); antiAIDS agent; candidiasis; clinical research; epidemiology; homeless; human subject; immunoregulation; opportunistic infections; oral leukoplakia; oral pharyngeal disorder; therapy compliance; warts

Our group has contributed to the identification and characterization of the role of oral lesions in HIV disease since the beginning of the epidemic. AIDS initially affected relatively affluent gay white adult men; subsequently, it crossed economic, sexual, ethnic, age, and gender boundaries. Our studies to date of the natural history of HIV disease have reflected his spread of the epidemic. They have included intravenous drug users, heterosexual populations, hemophiliacs, women, children, adolescents, and persons from minority groups. As the epidemic changes, most recently and notably because of therapeutic advances, it is important to chart the corresponding changes in the frequency and significance of HIV-related oral lesions. In Aim 1 we will examine the effects of use of highly active anti-retroviral therapy (HAART) on the prevalence and incidence of oral lesions in adolescent and adult men and women who primarily come from minority ethnic groups. We will examine the effect of HAART on the prognostic value of oral lesions for AIDS. In Aim 2 we will examine the association between failure of HAART and the prevalence of oral lesions. We will conduct these studies in a cohort of homeless persons and a cohort of adolescents, since non-compliance with HAART by members of both these groups places the wide population at high risk of treatment-resistance forms of HIV. In Aim 3 we will analyze the relationship between oral lesions and the specific immune response to the causative organisms off candidiasis, hairy leukoplakia, and oral warts, in relation to HAART use. We believe that our epidemiologic studies are unique with regard to the size and diversity of the cohorts available the quality of data available on the subjects, the extent and duration of the successful collegial interaction between the cohort investigators and our group, and the extraordinary level of cooperation and loyalty of the study subjects themselves. These characteristics focus our attention on research that can affect the prognosis of all HIV-infect persons.

自艾滋病开始流行以来，我们的小组一直致力于确定和描述口腔病变在艾滋病中的作用。艾滋病最初影响相对富裕的同性恋白色成年男子;随后，它跨越了经济，性别，种族，年龄和性别的界限。我们迄今对艾滋病毒疾病自然史的研究反映了这一流行病的传播。他们包括静脉注射吸毒者、异性恋人群、血友病患者、妇女、儿童、青少年和少数群体的人。随着流行病的变化，最近，特别是由于治疗的进步，重要的是要绘制相应的变化的频率和意义的艾滋病毒相关的口腔病变。在目标1中，我们将研究使用高效抗逆转录病毒疗法（HAART）对主要来自少数民族的青少年和成年男性和女性口腔病变的患病率和发病率的影响。我们将研究HAART对艾滋病口腔病变预后价值的影响。在目标2中，我们将研究HAART失败与口腔病变患病率之间的关系。我们将在一组无家可归者和一组青少年中进行这些研究，因为这两个群体的成员不遵守HAART使广大人群处于艾滋病毒耐药形式的高风险中。在目标3中，我们将分析口腔病变与对念珠菌病、毛状白斑和口腔疣的病原体的特异性免疫应答之间的关系，以及HAART的使用。我们相信，我们的流行病学研究在以下方面是独一无二的：可用队列的规模和多样性、受试者可用数据的质量、队列研究者与我们小组之间成功的合议互动的程度和持续时间，以及研究受试者本身的非凡合作和忠诚度。这些特点使我们集中注意力于可能影响所有艾滋病毒感染者预后的研究。