A phase III multicentre blinded randomised controlled clinical non-inferiority trial of cryopreserved platelets vs. conventional liquid-stored platelets for the management of post-surgical bleeding.

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Cryopreservation extends platelet shelf-life from 5 days to 2 years. However, evidence is insufficient for widespread use. Our recent 121-patient pilot trial found encouraging results. We now propose an 808-patient definitive trial in bleeding surgical patients, measuring blood loss, transfusion requirement, complications, and cost. Even if cryopreserved platelets are only equivalent to liquid-stored platelets, their longer shelf-life would justify rapid change in clinical practice worldwide.