A phase III trial comparing adjuvant versus salvage radiotherapy for high risk patients post radical prostatectomy

比较根治性前列腺切除术后高危患者的辅助放疗与挽救放疗的 III 期试验

• 批准号: nhmrc : 569293
• 负责人: A/Pr Andrew Kneebone
• 金额: $ 54.62万
• 依托单位: The University of Newcastle
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/phase-iii-trial-radical-prostatectomy/77599
• 关键词: phase; III; trial; comparing; adjuvant

About half of all patients Treated with an operation to remove their prostate cancer have a high chance of the cancer coming back. Giving immediate radiotherapy to all patients will improve cure rates but does not benefit all men and can cause significant side effects. This study explores whether it is safe to wait and only give radiotherapy when there is a rising PSA after surgery indicating active cancer. A total of 470 men from Australasia will enter this study comparing the two approaches.

大约一半接受手术切除前列腺癌的患者有很高的癌症复发的机会。对所有患者立即进行放射治疗将提高治愈率，但并不能使所有男性受益，并可能导致严重的副作用。这项研究探讨了当手术后PSA升高表明癌症活动时，等待并仅给予放射治疗是否安全。来自澳大拉西亚的470名男性将参加这项研究，比较两种方法。