A polypill to prevent genome damage

防止基因组损伤的多药丸

• 批准号: nhmrc : 464895
• 负责人: Ms Peta Forder
• 金额: $ 27.14万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/polypill-prevent-genome-damage/96325
• 关键词: polypill; prevent; genome; damage

It has become increasingly evident that damage to the genetic material in cells (DNA) is a fundamental initiating cause of cancer and accelerated ageing. Furthermore it has been shown recently that moderate deficiencies of certain vitamins and minerals can cause damage to DNA at a level that is observed for carcinogenic doses of radiation and toxic chemicals. In addition studies have shown that supplementation with certain vitamins resulted in a reduction of damage to DNA. The aims of this research is to determine whether daily intake of a pill containing certain vitamins and minerals causes a reduction in DNA damage in blood cells. The expected ultimate outcome is a cancer prevention strategy based on reducing the risk of damage to DNA.

越来越明显的是，细胞遗传物质 (DNA) 的损伤是癌症和加速衰老的根本原因。此外，最近的研究表明，某些维生素和矿物质的中度缺乏会导致 DNA 损伤，其程度达到致癌剂量的辐射和有毒化学物质的水平。此外，研究表明补充某些维生素可以减少 DNA 损伤。这项研究的目的是确定每天服用含有某些维生素和矿物质的药片是否会减少血细胞中的 DNA 损伤。预期的最终结果是基于降低 DNA 损伤风险的癌症预防策略。