TELOMERE FUNCTION DURING MEIOSIS IN FISSION YEAST
裂殖酵母减数分裂过程中的端粒功能
基本信息
- 批准号:6343073
- 负责人:
- 金额:$ 31.36万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1999
- 资助国家:美国
- 起止时间:1999-01-01 至 2003-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Telomeres are the DNA-protein complexes that form the ends of eukaryotic
linear chromosomes and protect their integrity. Telomeres are a focus
of research on aging (which is accompanied by gradual telomere loss) and
tumorigenesis (which requires stabilization of telomere length). Recent
work suggests that telomeres might play roles in sexual reproduction as
well, as they become associated with the spindle pole bodies (SPBs) and
lead chromosome movements during pre-meiotic stages in fission yeast.
The fission yeast telomere protein Taz1 is a key regulator of telomere
length, structure and position effects, but is critical for viability
only in cells that have initiated the sexual cycle. Indeed, Taz1p is
required for pre-meiotic telomere clustering at the SPBs, the absence
of which leads to aberrant meiotic recombination and segregation. Taz1p
is the first protein shown to be involved in telomere-SPB associations
and thus provides an unprecedented foothold for studying the mechanisms
underlying meiotic chromosomal rearrangements and the roles of these
rearrangements in sexual development. The proposed work addresses five
questions, using cytological, molecular genetic, and physiological
approaches: (1) What is the role of telomere clustering at SPBs during
meiosis and what processes depend on pre-meiotic chromosomal alignment?
(2) What are the signals that lead from the pheromone response to the
pre-meiotic chromosomal rearrangements? (3) Under what conditions is
Taz1p important for mitotic growth and what role does it play under such
conditions? (4) As a corollary to 2 and 3, is Taz1p regulated by
phosphorylation? (5) What proteins interact with Taz1p to mediate or
participate in its meiotic function? These studies will greatly expand
our knowledge of telomere function during sexual reproduction and under
stress. Given that telomere culstering during meiosis has been observed
in many eukaryotes, and that the human telomere protein hTRF1 is
structurally and functionally homologous to Taz1p these studies should
also illuminate processes involved in human meiosis.
端粒是构成真核生物末端的dna -蛋白质复合物
项目成果
期刊论文数量(0)
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JULIA S COOPER其他文献
JULIA S COOPER的其他文献
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{{ truncateString('JULIA S COOPER', 18)}}的其他基金
TELOMERE FUNCTION DURING MEIOSIS IN FISSION YEAST
裂殖酵母减数分裂过程中的端粒功能
- 批准号:
2773491 - 财政年份:1999
- 资助金额:
$ 31.36万 - 项目类别:
TELOMERE FUNCTION DURING MEIOSIS IN FISSION YEAST
裂殖酵母减数分裂过程中的端粒功能
- 批准号:
6138714 - 财政年份:1999
- 资助金额:
$ 31.36万 - 项目类别:
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