IN VIVO MICROSCOPY TECHNOLOGIES & APPLICATIONS: MICRO PET & MICRO CT

体内显微镜技术

• 批准号: 6348193
• 负责人: ELAINE G FITZSIMONS
• 金额: $ 1.5万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2001-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6348193
• 关键词: Mammalia; biological products; biomedical resource; ear; hearing; human tissue; nuclear magnetic resonance spectroscopy

With the aid of MR microscopy, the mustached bat, pteronotus parnellii, has been shown to have normal enlargements (hydrops) in certain regions of the cochlea (scala media). These enlargements occur in specific areas related to very sharp tuning. It is important to determine if this is a morphological feature common to all cochleas in regions of greatest sensitivity. It is also important to determine if this is related primarily to high frequencies and to address the question as to whether there are morphological differences among animals specialized for high vs. low frequency hearing. The purpose of this research is to obtain high resolution images which will allow us to reconstruct the scalae in several species of small mammals. To do this we propose to use two rodents (gerbils, guinea pigs) whose frequency sensitivity and hearing capacities are well documented. In addition to pteronotus, we will use the bat Eptesicus fuscus whose hearing capacities are very different from those of the mustached bat.

在磁共振显微镜的帮助下，胡子蝙蝠，pteronotus parnellii，已被证明有正常的扩大（水肿）， 耳蜗的某些区域（中阶）。 这些放大 发生在与非常尖锐的调谐相关的特定区域。 重要的是 以确定这是否是所有耳蜗共有的形态特征 在最敏感的地区。 同样重要的是要确定 如果这主要与高频有关并为了解决 问题是，是否存在形态学差异， 专门用于高频和低频听觉的动物。 目的 这项研究的目的是获得高分辨率的图像， 我们重建了几种小型哺乳动物的鳞片。 到 为此，我们建议使用两种啮齿动物（沙鼠，豚鼠）， 频率敏感性和听力能力是有据可查的。 在 除了翼龙，我们将使用蝙蝠Eptesicus fuscus， 听觉能力与小胡子蝙蝠有很大的不同